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Sophie Barthes (born 1974) is a French-American film director and screenwriter best known for her 2009 film Cold Souls.

Barthes was born in France and was raised in South America and the Middle East. She moved to New York in 2001 to attend the Columbia University School of the Arts.

Barthes' short film Happiness, which tells the story of a woman who purchases a box of happiness and cannot decide if she should open it, was shown at the 2007 Sundance Film Festival. The film was well-received and earned her a place in the Sundance Institute's Screenwriters Lab, where she began to write the screenplay for her first feature film, Cold Souls. Barthes had first begun to develop the idea for Cold Souls in 2005, after she had a dream about Woody Allen having his soul extracted. The film, directed by Barthes, premiered at the 2008 Sundance Film Festival, where it was nominated for the Grand Jury Prize. It was released in August 2009, and starred Paul Giamatti as a fictionalized version of himself who decides to have his soul removed.