Karen Lee Orzolek (born November 22, 1978) is a South Korean-born American singer, musician, and songwriter. She is the lead vocalist for the indie rock band Yeah Yeah Yeahs.

She was born in Seoul, South Korea, the daughter of a Korean mother and a Polish father. The family eventually moved to Englewood, New Jersey, where she grew up and graduated from Dwight-Englewood School. About her childhood, she stated that "it's almost embarrassing how well-behaved I was, which is probably why I do things like spit water on myself on stage as an adult". She attended Oberlin College before transferring to New York University's Tisch School of the Arts.

O is known as the lead vocalist for the band Yeah Yeah Yeahs. She has also been noted for her sense of fashion, wearing ostentatious outfits made by her friend, fashion designer Christian Joy. In the early days of the band, she became well-known for her outrageous antics during live shows. Their first ever gig was opening for the White Stripes in 2000.

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