Sutter Keely lives in the now. It's a good place for him. A high school senior, charming and self-possessed, he's the life of the party, loves his job at a men's clothing store, and has no plans for the future. A budding alcoholic, he's never far from his supersized, whiskey-fortified thirst-master cup. But after being dumped by his girlfriend, Sutter gets drunk and wakes up on a lawn with Aimee Finecky hovering over him. She's different: the "nice girl" who reads science fiction and doesn't have a boyfriend. While Aimee has dreams of a future, Sutter lives in the impressive delusion of a spectacular now, yet somehow, they're drawn together.

In 1957, when second-graders Bryce Loski and Julianna "Juli" Baker first meet, Juli knows it's love, but Bryce isn't so sure and tries to avoid Juli. By the sixth grade, in 1961, Bryce tries to get rid of Juli by dating Sherry Stalls, whom Juli despises. However, Bryce's best friend, Garrett, takes an interest in Sherry and eventually tells her the truth about Bryce asking her out; she doesn't take it well. From Juli's perspective, Bryce returned her feelings, but was shy. After finding out Bryce and Sherry broke up, she thought she could have Bryce back. But then they reconsider their decisions as time goes on. In 1962, Bryce's grandfather Chet Duncan moves in with the family. Chet has different views about Juli. There's a large, old sycamore tree that Juli loves which no one else understands. One day, it's cut down by a group of landscapers so a house can be built there, despite Juli's opposition. She becomes very depressed afterwards, as the tree let her see the world in a more enlightened way. Her father gives her a painting of the tree.

Dean Pereira and Cindy Heller Pereira are a young, working class married couple - Dean currently working as a painter, and Cindy working as a nurse in a medical clinic - with a young daughter named Frankie. Despite their relatively tender ages, they are both ravaged by the life they've eked out together and by the experiences they've had leading into their marriage. Dean, a high school drop out, comes from a broken home, where he never really had a mother figure. He never saw himself getting married or having a family despite falling in love at first sight with Cindy. He doesn't have any professional ambition beyond his current work - which he enjoys since he feels he can knock off a beer at 8 o'clock in the morning without it affecting his work - although Cindy believes he has so much more potential in life. Cindy also comes from a dysfunctional family, with her own mother and father not setting an example of a harmonious married or family life. One of her previous serious relationships was with Bobby Ontario, that relationship which has a profound affect on many aspects of her marriage to Dean. Dean and Cindy head off on an overnight getaway together without Frankie, the getaway which may provide a clearer picture if their marriage can survive its many issues.

Against medical advice and without the knowledge of her husband Pat Solatano Sr., caring Dolores Solatano discharges her adult son, Pat Solatano Jr., from a Maryland mental health institution after his minimum eight-month court ordered stint. The condition of the release includes Pat Jr. moving back in with his parents in their Philadelphia home. Although Pat Jr.'s institutionalization was due to him beating up the lover of his wife Nikki, he was diagnosed with bipolar disorder. Nikki has since left him and has received a restraining order against him. Although he is on medication (which he doesn't take because of the way it makes him feel) and has mandatory therapy sessions, Pat Jr. feels like he can manage on the outside solely by healthy living and looking for the "silver linings" in his life. His goals are to get his old job back as a substitute teacher, but more importantly reunite with Nikki. He finds there are certain instances where he doesn't cope well; however, no less so than some others who have never been institutionalized, such as his Philadelphia Eagles obsessed father who has resorted to being a bookie to earn a living, his best friend Ronnie who quietly seethes over the control wielded by his wife Veronica, and Veronica's widowed sister, Tiffany Maxwell, a girl with problems of her own. In their fragile mental states, Pat Jr. and Tiffany embark on a love/hate friendship based primarily on what help the other can provide in achieving their individual goals. But they may reevaluate their goals as their relationship progresses.

In the early 1960's, sixteen-year-old Jenny Mellor (Carey Mulligan) lives with her parents in the London suburb of Twickenham. On her father Jack's (Alfred Molina's) wishes, everything that Jenny does is in the sole pursuit of being accepted into Oxford, as he wants her to have a better life than him. Jenny is bright, pretty, hard working, but also naturally gifted. The only problems her father may perceive in her life is her issue with learning Latin, and her dating a boy named Graham (Matthew Beard), who is nice, but socially awkward. Jenny's life changes after she meets David Goldman (Peter Sarsgaard), a man over twice her age. David goes out of his way to show Jenny and her family that his interest in her is not improper and that he wants solely to expose her to cultural activities which she enjoys. Jenny quickly gets accustomed to the life to which David and his constant companions, Danny (Dominic Cooper) and Helen (Rosamund Pike), have shown her, and Jenny and David's relationship does move on to becoming a romantic one. However, Jenny slowly learns more about David, and by association, Danny and Helen, and specifically how they make their money. Jenny has to decide if what she learns about them and leading such a life is worth forgoing her plans of higher education at Oxford.

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