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"This Podcast Will Kill You" is an American podcast hosted by disease ecologists and epidemiologists Erin Welsh and Erin Allmann Updyke. Its first full-length episode was released on October 31, 2017. New episodes were released weekly until the second season, when they were released every two weeks. Each week a different disease is covered, the majority of which being infectious, but some exceptions have occurred, such as scurvy in episode 19.

"This Podcast Will Kill You" is part of the Exactly Right Podcast Network, created by the hosts of "My Favorite Murder."

Each episode is about an hour in duration and generally starts with a firsthand account of someone affected by the disease. After that, the hosts create a mixed drink that is connected to the disease, called a 'Quarantini', in a segment known as 'Quarantini time'. After this introduction, the biology of the disease is explained, then history, epidemiology, and finally, the disease's effect on the modern world. Generally, Welsh tells the history of the disease and Updyke explains the biology epidemiology. Finally, the hosts cite the sources used to present the information, and supply a link to their website where the sources can be found.