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Nic and Jules are in a long term, committed, loving but by no means perfect same-sex relationship. Nic, a physician, needs to wield what she believes is control, whereas Jules, under that control, is less self-assured. During their relationship, Jules has floundered in her "nine to five" life, sometimes trying to start a business - always unsuccessfully - or being the stay-at-home mom. She is currently trying to start a landscape design business. They have two teen-aged children, Joni (conceived by Nic) and Laser (by Jules). Although not exact replicas, each offspring does more closely resemble his/her biological mother in temperament. Joni and Laser are also half-siblings, having the same unknown sperm donor father. Shortly after Joni's eighteenth birthday and shortly before she plans to leave the house and head off to college, Laser, only fifteen and underage to do so, pleads with her to try and contact their sperm donor father. Somewhat reluctantly, she does. He is late thirty-something Paul, a co-op farmer and restaurateur. Despite his seemingly successful businesses, Paul has always shirked responsibility, most specifically in his personal life. After Joni and Laser meet with Paul, Nic and Jules learn what their children have done and, although they don't want Paul infiltrating their lives, want to meet him - especially as Joni and Laser seem to want to maintain some sort of relationship with him. As Paul's relationship with the entire family grows (which includes his hiring Jules to design and construct his backyard), they have an effect on what he wants in life. In turn, he affects their family dynamic as well as each person's relationships outside of it.

Violet and her two cohorts attempt to help their "less-fortunate" students at Seven Oaks College - primarily by running a Suicide Prevention Centre and offering their off-beat advice whenever they get a chance. Violet's newest rescue is transfer student, Lily, and Violet wants to teach her how to talk and dress properly, and how to select appropriate men to be interested in. Along their way in helping everybody at the college, the damsels teach the fraternity doofi to hit the books, they get their hearts broken, but then attempt to start an international dance craze.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Friendship, love, and coming of age in New York City, summer of 1994. Luke Shapiro has just graduated from high school, sells marijuana, and trades pot for therapy from a psychologist, Dr. Jeffrey Squires. Luke is attracted to a classmate, Stephanie, who's out of his league and Squires' step-daughter. By July, he's hanging out with Stephanie, taking her on his rounds selling pot out of an ice-cream pushcart. Then things take a turn. In the background, Squires and his wife as well as Luke's parents are having their troubles.

Celeste and Jesse have been best friends forever. They dated in high school, got married, and now they're getting divorced. Their best friends don't think they can maintain their friendship throughout the dissolution of their marriage, but Celeste and Jesse don't think there will be a problem. But that's before Jesse gets into a relationship that Celeste doesn't think he can handle, and Celeste finds it harder to move on than she originally thought.

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

Hollywood actor Johnny Marco, nested in his luxury hotel of choice, is a stimulated man. Drinking, parties and women keep a creeping boredom under wraps in between jobs. He is the occasional father of a bright girl, Cleo, who may be spoiled but doesn't act it. When Cleo's mother drops her off and leaves town, Johnny brings her along for the ride, but can he fit an 11-year-old girl into his privileged lifestyle?

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who lives in the building and fakes her death to get the girl to let him in her apartment but holds a butcher knife between them. So it goes and he is no longer living in his car. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her to get out of the apartment, cooking, washing her hair. Both have demons and, as their stories become more clear, his addictive personality and her sex nausea may be on a collision course.

Although cheerful, friendly, intelligent, well-dressed, authentic and wealthy, Charlie Bartlett has problems. With his father gone and his mother loopy and clueless, he's been expelled from every private school for his victimless crimes. Now he's in a public school getting punched out daily by the school thug. He ever longs to be popular - the go-to guy - and the true crux of his troubles is that he invariably finds the means to this end, whatever that might be. At Western Summit High, he makes peace with his tormentor by going into business with him - listening to kids' problems and selling them prescription drugs. Charlie's a hit, but attraction to Susan (daughter of the school's laissez-faire principal), new security cameras on campus, a student's overdose, and Charlie's open world view all converge to get him in serious trouble. Can this self-made physician possibly heal himself and just be a kid?

Do we ever get what we want? Brian sells mattresses in a warehouse store. His father and older brothers have material success; he wants a child. He's applied to adopt a baby from China. A man who appears homeless seems to be stalking Brian with violent intent. He meets Happy, the daughter of a rich, quirky customer. She doesn't stick to anything, but she and Brian hit it off, except for her vomiting when she learns about his adoption idea. He wants her to meet his family, and there's a call about the adoption. What will Happy do?

Jerome, a kid from the suburbs who loves to draw, goes to New York City's Strathmore College for his freshman year as a drawing major. Competition and petty jealousy consume faculty and students, with an end-of-first-semester best-student award held out as a grand plum. Worse, a strangler is on the loose, killing people on or next to campus. The idealistic Jerome falls in love with Audrey, a student who models for life-drawing classes and who responds to his sweetness. But he has a rival: the clean-cut, manly Jonah, also a first-year drawing student, whose primitive work draws raves and Audrey's attention. As cynicism seems to corrode everything, Jerome is desperate to win.

Nora Wilder is freaking out. Everyone around her is either in a relationship, married, or has children. Nora is in her thirties, alone with job she's outgrown and a mother who constantly reminds her of it all. Not to mention her best friend Audrey's "perfect marriage". But after a series of disastrous dates, Nora unexpectedly meets Julien, a quirky Frenchman who opens her eyes to a lot more than love.

We like Florence: she's considerate, sweet, pretty, and terrific with kids and dogs. She's twenty-five, personal assistant to an L.A. family that's off on vacation. Her boss's brother comes in from New York City, fresh from a stay at an asylum, to take care of the house. He's Roger, a forty-year-old carpenter, gone from L.A. for fifteen years. He arrives, doesn't drive, and needs Florence's help, especially with the family's dog. He's also connecting with former band-mates - two men and one woman with whom he has a history. He over-analyzes, has a short fuse, and doesn't laugh at himself easily. As he navigates past and present, he's his own saboteur. And what of Florence? is Roger one more responsibility for her or something else?

Craig is a high-school junior in the gifted program, infatuated with his best friend's girl. When he realizes he's suicidal, he checks himself into the psychiatric ward of a hospital, thinking they'll do an observation, help him, and send him home in time for school the next day. Once in, however, he must stay for a week; the juvenile ward is being renovated, so he's in with adults as well as a few youths. Bobby, a man with a young daughter, shows him around; Craig notices Noelle, about his age. He tries to keep his friends from finding out where he is. He draws, goes to therapy, sings, helps Bobby rehearse an interview. Is this the stuff of insight?

At 16, Nick Twisp is wry about his teen funk: he lives in Oakland with his sex-addled mother; his father's child support is her meal ticket. While camping in Ukiah, Nick meets Sheeni: for him, it's love at first sight. Nick has to figure out how to get his father a job in Ukiah, then how to get sent to live with his father, then how to get close to Sheeni, whose religious parents may want her sent away from temptation to a boarding school. There's also Sheeni's all-American boyfriend to contend with. Overwhelmed by the challenges, Nick's about to give up when he conjures an alter ego who whispers revolt into his ear. Nick is not altogether hapless, but can this end well?

Believing the quote that you are born alone, die alone and everything else is an illusion, George doesn't see the point of life, school, or homework. Then he meets Sally and he now has a reason to go to school and make friends, even if he's not ready to admit to himself or to her that he likes her. The school's principal and art teacher introduce him to an alumni, and successful artist, Dustin, who can help guide George along life's path, but other distractions start surfacing, and George might not even be able to graduate from high school.

In 2003, 38-year-old graphic artist Oliver Fields has just lost his father Hal to cancer, 5 years after his mother Georgia's death. Oliver is naturally sullen because of his relationships with his parents growing up (especially his mother, who had a unique view of life) and watching their cordial but somewhat distant marital relationship, but he's more so now as he deals with his personal losses. He embarks on a relationship with French actress Anna, hoping that his re-energized relationship with Hal following Georgia's death, and Hal's new outlook on life, will show him how to act in a loving relationship. After Georgia's death, Hal came out of the closet and began to live with a new joie de vivre and have an open relationship with Andy, a much-younger man. Oliver's relationship with Anna has other obstacles, including her own vagabond lifestyle and Oliver inheriting Arthur, Hal's very needy Jack Russell terrier.

Iris invites her friend Jack, who's mourning his brother's death, to her father's cottage for some alone time to recuperate, but they discover that Iris' sister Hannah is already there recovering from a recent break-up. One whole bottle of tequila later, Jack and Hannah wake up to find Iris at the door. All three have secrets they're trying to keep and feelings they're trying to sort out.