In 2078, in the wake of a global pandemic of vampirism, a sub-species of disease-modified humans find themselves possessing extraordinary agility, enhanced strength, incredible stamina, and acute intelligence. As a result, humankind is now pushed to the brink of a brutal, worldwide civil war. Now, against the backdrop of the imminent confrontation between the government and the "others", Ultraviolet, an infected beautiful Haemophage, finds herself caught in the middle, protecting Six, a helpless nine-year-old boy who has been marked for death by the military forces of Daxus. Can Ultraviolet destroy Daxus' ultimate anti-Haemophage weapon?

Years after the Raccoon City disaster, Alice is on her own; aware that she has become a liability and could endanger those around her, she is struggling to survive and bring down the Umbrella Corporation led by the sinister Albert Wesker and head researcher Dr. Isaacs. Meanwhile, traveling through the Nevada Desert and the ruins of Las Vegas, Carlos Olivera, L.J., and new survivors K-Mart, Claire Redfield, and Nurse Betty must fight to survive extinction against hordes of zombies, killer crows and the most terrifying creatures created as a result of the deadly T-Virus that has killed millions.

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