Ganta, the sole survivor of the brutal murder of his entire class, is framed and ends up falsely convicted for it. During the massacre the real killer embeds a red crystal in him. Ganta is sent to a privately owned prison which has a rather different and perverted take on incarceration, entertaining the masses by performing dangerous games in exchange for privileges. Every inmate he encounters has their own goals, survival being the main one, and it is now up to him to survive this and maybe even prove his innocence.

There is a war going on between masters and servants in order to attain the Holy Grail. Each master can call up one servant each, and their task is to eradicate the other servants, either by defeating them or killing their master. When there is only one master or servant left, he or she is granted the Holy Grail, and any wish they desire will come true.

After the outbreak of the unidentified virus "Lost Christmas" in 2029, Japan has been under the control of a multi-nation organization called GHQ. Ohma Shu is a 17 year old boy who has a psychic power in his right hand. He can use the power "Ability of King" to extract tools or weapons from his friends. He has been avoiding making trouble for others but his life changes when he meets a girl Yuzuriha Inori, a member of a resistance guerrilla group called "Funeral Parlor", whose members pilot mecha weapons to fight against the government.

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