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Brian Kessler, a journalist researching serial killers, and his photographer girlfriend Carrie set out on a cross-country tour of the sites of the killings. Sharing the ride and their expenses are Early Grayce, a paroled white trash criminal, and his girlfriend Adele. As the trip progresses, Early begins to appear more and more unstable, and Brian and Carrie begin to fear that they may have a real-life killer in the back seat of their car.

Nearly two years after having gone amiss in Africa, renowned anthropologist Dr. Ethan Powell (Sir Anthony Hopkins) is caught committing a crime and subsequently imprisoned in a Florida mental institution, where aspiring psychiatrist Dr. Theo Caulder (Cuba Gooding, Jr.) takes over his important case. Dr. Powell, who has been with a group of gorillas during all that time, is not talking at all, and seems to be living in a dreamworld. Very slowly, Dr. Caulder manages to reach Ethan and starts finding out why he killed two of the poachers. Yet, Theo's case is not just about why the murders have happened, but also about how Dr. Powell became the being he is in the first place. With Ethan's silence broken, Theo is introduced into a world beyond common human comprehension: The true nature of being. He learns that mankind's control of everything is a mere illusion and that the true values of existence can't be found so easily. Ethan changes Theo's view of things forever.

An admired high school hockey player with a bright future foolishly takes a drive in the night with his girlfriend and two other friends with his headlights off with devastating results. The former athlete is left with a brain injury that prevents him from remembering many things for extended periods of time. To compensate, he keeps notes in a small notebook to aid him in remembering what he is to do. He also lives with a blind friend who aids him. Obviously, with the mental incapacitation, he is unable to have meaningful work. Thus he works as a night cleaning man in a bank. It is there he comes under the scrutiny of a gang planning to rob the bank. The leader befriends him and gets him involved with a young woman who further reels him in. After they get close and after reeling him in with his own failures, the bank plan unfolds. Confused but wanting to escape his current existence, he initially goes along with the scheme. After realizing he is being used, he attempts to stop the robbery, which of course immediately goes awry.

Quadriplegic ex-cop Lincoln Rhyme was looking forward to his assisted suicide when he got the news: some sicko was abducting people in a taxi and leaving them to die in particularly sadistic ways. With time counting down between each abduction and possible death, Rhyme recruits rather-unwilling Amelia Donaghy, haunted by her cop father's suicide and thinking she's next, into working the crime scenes to track down the killer.

Chicago advertising executive Charles 'Chaz' Schine is mentally worn down by his useless teacher wife Deanna and their equally ingrate daughter Amy, whose bad diabetes requires experimental, uncovered treatment that would exhaust their life savings. When foxy investment adviser Lucinda Harris volunteers to pay his ticket when he arrive son the commuter train without cash, they soon start an affair. Taking her to a tacky hotel, they are held at gunpoint by thug 'Frenchie' LaRoche, who rapes her having knocked Chaz down, robs their wallets and calls him afterward, blackmailing a small fortune not to tell his wife. Paying through equally abusive Dexter only incurs more demands and abuse, until Chaz brings along ex con office mail boy Winston Boyko, who promises to scare away, but is shot by LaRoche, leaving Chaz to deal with the corpse, police detective Church being a friend of Winston's. Only when bled dry, Chaz finds out Lucinda is a stolen identity, part of an elaborate setup. His ill-planned vengeance, as lawyer friend Jerry sees no legal way without timely complaints from him and Lucinda, starts a cycle of bloodshed and other unpleasant surprises for most involved.

Earl Brooks is a highly respected businessman and was recently named Portland's Man of the Year. He hides a terrible secret however: he is a serial killer known as the Thumbprint Killer. He has been attending AA meetings and has kept his addiction to killing under control for two years now but his alter ego, Marshall, has re-appeared and is pushing him to kill again. When he does kill a couple while they are making love, he is seen and photographed by someone who also has his own death and murder fetish. In a parallel story, the police detective investigating the murder is having problems of her own. She is going through a messy divorce and a violent criminal who had vowed revenge some years before has escaped from prison and is after her.

An intertwined drama about the United States' war on drugs, seen through the eyes of a once conservative judge, now newly-appointed drug czar, his heroin-addicted daughter, two DEA agents, a jailed drug kingpin's wife, and a Mexican cop who begins to question his boss's motives.

On a warm September evening, college professor Ethan Learner, his wife Grace, and their daughter Emma are attending a recital. Their 10-year-old son Josh is playing cello - beautifully, as usual. His younger sister looks up to him, and his parents are proud of their son. On the way home, they all stop at a gas station on Reservation Road. There, in one terrible instant, he is taken from them forever. On a warm September evening, law associate Dwight Arno and his 11-year-old son Lucas are attending a baseball game. Their favorite team, the Red Sox, is playing - and, hopefully, heading for the World Series. Dwight cherishes his time spent with Lucas. Driving his son back to his ex-wife, Lucas' mother Ruth Wheldon, Dwight heads towards his fateful encounter at Reservation Road. The accident happens so fast that Lucas is all but unaware, while Ethan - the only witness - is all too aware, as a panicked Dwight speeds away. The police are called, and an investigation begins. Haunted by the tragedy, both fathers react in unexpected ways, as do Grace and Emma. As a reckoning looms, the two fathers are forced to make the hardest choices of their lives.

In California, Caucasian Chris Mattson and his African-American wife Lisa Mattson move into a house in a gated community. Their racist, dysfunctional next-door neighbor is the abusive LAPD Officer Abel Turner who feels uncomfortable with the relationship of the newcomers and transforms their lives into Hell on Earth.

After escaping death by the skin of his teeth while on the hunt for the elusive madman, Dr Hannibal Lecter, the now-retired and emotionally scarred FBI agent, Will Graham, finds himself back in action. Reluctantly, as yet another monstrous serial killer known as "The Tooth Fairy" terrorises Baltimore, Graham turns to Lecter, the evil mastermind who's been under lock and key for three long years, to lend a hand in this challenging and time-sensitive case. But, to delve deep into the demented mind of a killer, one must first face his inner demons, and Will already knows that his insane imprisoned assistant is a gifted manipulator. Can Graham find the horrifying Red Dragon in time before another family suffers?

As children, Lorenzo Carcaterra - Shakes to his friends - Michael Sullivan, Tommy Marcano, and John Reilly were inseparable. They grew up in Hell's Kitchen, a far from perfect neighborhood, one filled as Shakes says with scams and shake downs, but one where the rules were known and easily understood by its residents. The one adult who they admired was Father Bobby Carelli, who understood them as kids more than most adults and more than he himself would like to admit. In 1967, their lives would change forever when a typical teenage prank went wrong which led to the four of them being sentenced to various terms at Wilkinson Home for Boys, a reformatory. There, they were physically, emotionally and sexually abused primarily by Sean Nokes, the predatory lead guard of their cell block, and fellow guards Ralph Ferguson, Henry Addison, and Adam Styler, although there were other decent figures of authority at the home, including a few other guards. Their time at the home affected the four, not all who were able to emerge from the experience to regroup their lives. In their want to forget about the experience, they made a vow not to talk about it either between themselves or with others. Fast forward thirteen years, with Tommy and Johnny being career criminals, Michael an assistant district attorney and Shakes a newspaper writer, their friendship on the surface more loose than it was when they were children. When Tommy and John unexpectedly spot Nokes at a local restaurant, it leads to Shakes and Michael banding together to exact revenge not only on Nokes but all four of the guards who abused them. Michael had long mapped out a plan even before Tommy and John saw Nokes, but that sighting and its aftermath alters the plan. Beyond the precarious position Tommy and John place themselves into, Michael has the most to lose even if the plan succeeds. Most of the plan implementation is left to Shakes who has to enlist the machine of Hell's Kitchen, including mob boss King Benny, and their childhood friend, social worker Carol Martinez, who currently is John's girlfriend. Beyond co-opting aging lawyer Danny Snyder, who admits he may not be the best choice as an alcoholic who is no longer near the top of his game, the plan is threatened by a key piece, the need for an unreproachable figure to perjure him or herself, that person who Michael and Shakes hopes will be Father Bobby. Father Bobby, even if he knew of the abuse, may not be able to do his friends this enormous favor of an illegal nature, he who has to balance the morality of the situation in his own mind in deciding what to do.

After the murder of his beloved wife, Danny Parker is set adrift in a world where nothing is as it seems. On his journey he befriends slacker Jimmy the Finn and becomes involved in rescuing his neighbor Colette from her own demons. Danny is antagonized by undercover narcotics agents and sadistic dealer Pooh-Bear.

Jake Vig leads a small Los Angeles based team of grifters, each member who has his specific role in each con: Jake is the main man, Miles the adversary, Big Al the scared innocent bystander, and Gordo the dead shooting victim. He also has in his pockets crooked LAPD detectives Lloyd Whitworth and Omar Manzano who basically play themselves as needed. Beyond getting the money, the basic goal of each con is to ensure the mark is so scared by what has happened - usually being an accomplice in a "murder" - that he won't come back looking for the money. Jake learns the hard way that their latest mark, Louis Dolby, who they fleeced for $150,000, was carrying money for a criminal named King, who takes a no prisoners approach in getting even, he who knows who stole his money. Instead of returning the $150,000 to King, money which he no longer has anyway, Jake convinces King to parlay that money and a bit more into a bigger con against a mark of King's choice, that person being banker Morgan Price, a second generation mobster. The total take for this con is to be $5 million. Beyond co-opting a couple of inside people for this con, King wants one of his own men inserted - Lupus - and Jake also enlists the work of a female pickpocket he recently ran across named Lily, to who he is attracted. During the process, a small wrinkle occurs when they learn that Special Agent Gunther Butan with the US Customs Agency, an old adversary of Jake's, is currently after him, which means they either have to call off the international mission or watch more carefully their movements, with Jake not to be the one to carry any money across the border. But with a group of con artists working for the first time with new players, a question becomes are there any inside cons at play, especially in this case where Jake has more of a personal stake than usual.

Recently divorced Meg Altman and her daughter Sarah have bought a new home in New York. On their tour around the mansion, they come across the panic room. A room so secure, that no one can get in. When three burglars break in, Meg makes a move to the panic room. But all her troubles don't stop there. The criminals know where she is, and what they require the most in the house is in that very room.

John Holmes was a legend of the porn industry and revered in circles as a stud. But in 1981, years after his successful career and star fading, Holmes was a desperate man with his own internal demons to live up to. He's estranged from his wife, holding onto a relationship with his teenage mistress, and living as a junkie in search of his next fix. But one fateful night left four people dead and John as a key suspect in one of the most grisly murders in Los Angeles. Was he partly responsible for what happened at Wonderland Avenue?

In the midst of an elaborate conspiracy, an expert negotiator is driven to the edge when he's framed for the murder of his partner, as well as embezzling money from his department's pension fund. His only chance to prove his innocence is to take hostages himself, acquire the services of another expert negotiator, and find out who's running the conspiracy before it's too late.

The true story of serial killer Aileen Wuornos who was convicted of luring men to their death and eventually executed in 2002. In 1989, she was working as a prostitute and finally makes a friend when she meets and begins a relationship with a young woman, Selby. Determined to straighten out her life, she tries to find legitimate work but with little education and limited social skills, she fails at every turn. She starts working as a hooker hitching rides along the local interstate highway and after robbing a few clients has an encounter with a vicious client whom she kills in self-defense. After that however she just takes to killing clients taking their money and car. Once arrested she claims self-defense but is eventually convicted.

John Quincy Archibald's son Michael collapses while playing baseball as a result of heart failure. John rushes Michael to a hospital emergency room where he is informed that Michael's only hope is a transplant. Unfortunately, John's insurance won't cover his son's transplant. Out of options, John Q. takes the emergency room staff and patients hostage until hospital doctors agree to do the transplant.