Fearing it would compromise his career, lawyer Andrew Beckett hides his homosexuality and HIV status at a powerful Philadelphia law firm. But his secret is exposed when a colleague spots the illness's telltale lesions. Fired shortly afterwards, Beckett resolves to sue for discrimination, teaming up with Joe Miller (Denzel Washington), the only lawyer willing to help. In court, they face one of his ex-employers top litigators, Belinda Conine.

Alan Johnson has everything he needs to get through life: a good job, a beautiful and loving wife, and their wonderful children. Yet he feels isolated because he finds having a hard-working job and managing a family too much to handle and has no one to talk to about it. Charlie Fineman, on the other hand, doesn't have a job or a family. He used to have both until a terrible loss, and the grief caused him to quit his job and isolate himself from everyone around him. As it turns out, Alan and Charlie were roommates in college, and a chance encounter one night rekindles the friendship they shared. But when Charlie's problems become too much to deal with, Alan is determined to help Charlie come out of his emotional abyss.

Following the tragic death of their five-year-old son Frankie, Irish couple Johnny and Sarah Sullivan and their remaining two offspring, 10 year old Christy Sullivan and 5 year old Ariel Sullivan, emigrate illegally to the United States via Canada with little in their pockets. Their final destination is Manhattan where Johnny hopes to work as a stage actor. They move into a unit in a run town tenement housed primarily with drug addicts, transvestites and one tenant coined "the man who screams". They do whatever they can to eke out a supportive family environment in this difficult situation, the support which ultimately extends to those around them, most specifically "the screamer" who turns out to be an African-American artist named Mateo with AIDS. But the memory of Frankie hangs over the family in good and bad ways, especially as Sarah learns she's pregnant. Christy, who records their life's goings-on with her beloved camcorder, believes that the angel of Frankie has granted her three wishes, which she guards until absolutely needed.

After his death sometime in his 43rd year, suburbanite Lester Burnham tells of the last few weeks of his life, during which he had no idea of his imminent passing. He is a husband to real estate agent Carolyn Burnham and father to high school student Jane Burnham. Although Lester and Carolyn once loved each other, they now merely tolerate each other. Typical wallflower Jane also hates both her parents; the three suffer individually in silence in their home life. Jane tries to steer clear of both her parents. Carolyn, relatively new to the real estate business, wants to create the persona of success to further her career, aspiring to the professional life of Buddy Kane, the king of the real estate business in their neighborhood. Lester merely walks mindlessly through life, including at his job in advertising. His company is downsizing, and he, like all the other employees, has to justify his position to the newly hired efficiency expert to keep his job. Things change for Lester when he falls in love at first sight with Jane's more experienced classmate, Angela Hayes. Both Janie and Angela can see Lester's sexual infatuation with Angela, who courts such attention from any man as a sign that she is model material, she having once appeared in Seventeen and is a career to which she aspires. Lester's infatuation with Angela gives him a reenergized view on life, where he openly doesn't care anymore what anyone thinks about what he does, anyone except Angela. This infatuation coincides with the Fittses moving in next door: homophobic disciplinarian US Marine Colonel Frank Fitts who rules the house with a military fist (that fist being both figurative and literal), his semi-comatose wife Barbara Fitts, and their bright and quietly subversive 18-year-old son Ricky Fitts, who openly abides by his father's rules while behind the scenes lives by his own quite different perspective. Much like Lester's infatuation, Ricky immediately becomes infatuated with Jane; he considers girls like Angela as ordinary. The entry of Angela and the Fittses into the Burnhams' lives ultimately leads to each of the players confronting what is truly in his or her heart.

Sara Goldfarb (Ellen Burstyn) is a retired widow, living in a small apartment. She spends most of her time watching TV, especially a particular self-help show. She has delusions of rising above her current dull existence by being a guest on that show. Her son, Harry (Jared Leto) is a junkie but along with his friend Tyrone (Marlon Wayans) has visions of making it big by becoming a drug dealer. Harry's girlfriend Marion (Jennifer Connelly) could be fashion designer or artist but is swept along in Harry's drug-centric world. Meanwhile Sara has developed an addiction of her own. She desperately wants to lose weight and so goes on a crash course involving popping pills, pills which turn out to be very addictive and harmful to her mental state.

Theater director Caden Cotard is mounting a new play. Fresh off of a successful production of Death of a Salesman, he has traded in the suburban blue-hairs and regional theater of Schenectady for the cultured audiences and bright footlights of Broadway. Armed with a MacArthur grant and determined to create a piece of brutal realism and honesty, something into which he can put his whole self, he gathers an ensemble cast into a warehouse in Manhattan's theater district. He directs them in a celebration of the mundane, instructing each to live out their constructed lives in a small mock-up of the city outside. As the city inside the warehouse grows, Caden's own life veers wildly off the tracks. The shadow of his ex-wife Adele, a celebrated painter who left him years ago for Germany's art scene, sneers at him from every corner. Somewhere in Berlin, his daughter Olive is growing up under the questionable guidance of Adele's friend, Maria. He's helplessly driving his marriage to actress Claire into the ground. Sammy Barnathan, the actor Caden has hired to play himself within the play, is a bit too perfect for the part, and is making it difficult for Caden to revive his relationship with the alluringly candid Hazel. Meanwhile, his therapist, Madeline Gravis, is better at plugging her best-seller than she is at counselling him. His second daughter, Ariel, is disabled. And a mysterious condition is systematically shutting down each of his autonomic functions, one by one. As the years rapidly pass, Caden buries himself deeper into his masterpiece. Populating the cast and crew with doppelgangers, he steadily blurs the line between the world of the play and that of his own deteriorating reality. As he pushes the limits of his relationships, both personally and professionally, a change in creative direction arrives in Millicent Weems, a celebrated theater actress who may offer Caden the break he needs.

Extended essay