Flashback

In June, 1983, in Dutchess County, New York, Sebastian Cole joins his mother, step-father, and sister for dinner. Hank, Sebastian's step-father, drops a bomb: he announces he's changing sexes. Sebastian's sister splits immediately for California, and his mother takes him back to England. Jump ahead eight months, Sebastian is back in New York, knocking on Hank's door. Hank (now Henrietta, although all the surgeries aren't complete) takes Sebastian in and is his rock over the next few months of high school. Sebastian's "adventures" are mostly self-destructive.

Two sisters, 11-year-old Amanda and 16-year-old Laurel, run away from their different foster parents and sleep in model homes and wherever else they can. But when Laurel becomes pregnant. they realize they can't handle this crisis on their own. With nowhere else to turn, they decide to kidnap Elaine, a clerk in a baby-supply store. But Elaine seems to need Manny and Lo just as much as they need her.

While helicopters overhead spray against a Medfly infestation a group of Los Angeles lives intersect, some casually, some to more lasting effect. Whilst they go out to concerts and jazz clubs and even have their pools cleaned, they also lie, drink, and cheat. Death itself seems never to be far away, even on a fishing trip.

Enid and Rebecca after they finish the high school. Both have problems relating to people and they spend their time hanging around and bothering creeps. When they meet Seymour who is a social outsider who loves to collect old 78 records, Enid's life will change forever.

Seventh-grade is no fun. Especially for Dawn Weiner when everyone at school calls you 'Dog-Face' or 'Wiener-Dog.' Not to mention if your older brother is 'King of the Nerds' and your younger sister is a cutesy ballerina who gets you in trouble but is your parents' favorite. And that's just the beginning--her life seems to be falling apart when she faces rejection from the older guy in her brother's band that she has a crush on, her parents want to tear down her 'Special People's Club' clubhouse, and her sister is abducted....

Jennifer does not fit in. A total misfit, she's as wacky as a teenager can be. Goth-ed out with multiple piercings, tattoos, and dyed hair, she listens to strange music, watches vintage TV, eats primarily chocolate, and self injures. But now high school is over and she needs a job. Can she possibly have anything in common with the overweight middle-aged man in the haberdashery window? He gives her a job, not to mention a real friendship.

Successful Carolinian George Johnsten meets Chicago art gallery owner Madeleine at an electoral benefit art auction- love at first sight. Madeleine decides to meet a Southern original artist, so George seizes the opportunity to come along and present her to his North Carolina parents Eugene and Peg, drop-out brother Johny and his high-pregnant wife Ashley. Confronting the outsider soon opens a can of worms as emotions revive or emerge, like admiration and jealousy.

Vivian's family are penniless nomads, moving from one cheap flat to another in Beverly Hills so she and her brothers can attend the city's schools. Uncle Mickey sends them money to survive. When Mickey's daughter Rita runs away from an asylum, Vivian's dad offers shelter to her if Mickey will pay for a plush flat. Vivian must babysit her adult cousin, making sure she gets to nursing school and avoids pills and booze. But Vivian has her own problems: she's curious about sex, likes an older neighbor kid, has inherited her mother's ample breasts, and wants a family that doesn't embarrass her. Can she help Rita, keep Uncle Mickey happy, and feel OK about her body and her family?

Seventeen year old Jason Slocumb, Jr. - Igby to most that know him - comes from east coast old money, the second son of self-absorbed and controlling Mimi Slocumb and medically-diagnosed schizophrenic Jason Slocum, Sr., the latter who has for several years been institutionalized in a Maryland psychiatric facility. While Igby's economics-studying Columbia-attending older brother Ollie Slocum has embraced and aspires to continue their wealthy life, Igby has rebelled against it, considering his brother a fascist (although he could soften that label to Republican). Because of Jason's situation, Mimi has largely left the role of male role model for Ollie and Igby to their godfather, D.H. Banes. Igby's rebellion has led to him being kicked out of one prep school after another, the latest, a military academy, from which Igby escapes before he can graduate. As such, Mimi and D.H. arrange for Igby to live in New York with Ollie for the summer while working for D.H. renovating some of his properties, before Mimi arranges for yet another strict school for the fall so that Igby can at least graduate. Igby is largely able to hide out for most of the summer with the help of Rachel, D.H.'s younger heroin addict mistress, and Sookie, a slightly older waitress with who he falls in love. An issue with Sookie and the aftermath of a joint mission with Ollie leads to Igby having a clearer picture of what his immediate future will look like.

A Baltimore sandwich shop employee becomes an overnight sensation when a photographer's photos he's taken of his weird family become the latest rage in the art world.

Iris can best be described as a wallflower. She begins her first day as a temp for the nondescript Global Credit Association by waiting in a chair for two hours. This sets the scene for her (mis)adventures with the other "corporate orphans", Margaret, Paula and Jane. Led by Margaret, they find subtle ways to lessen the ennui of corporate oppression. The tension escalates when the new permanent hire, Cleo, enters the picture.

While visiting an art museum, a nerdy college student named Adam meets an iconoclastic artist named Evelyn and is instantly smitten. As their relationship develops, she gradually encourages Adam to change in various ways that surprise his older friends, Jenny and Philip. However, as events progress, Evelyn's antics become darker and darker as her influence begins to twist Adam and his friends in hurtful ways.

A 16 year old Louisiana girl moves in with her homosexual half-brother and immediately starts coming on to his sexual partner, finally forcing him into an affair in which she becomes pregnant. The whole affair blows into a scandal exposing her school teacher brother and the true parent of the child is called into question as it is revealed that there have been a series of lovers.

Wilson Joel is a man in trouble. There's a searing pain in his gut that he can't tolerate and a dazed quietness to his struggle as he tries to maintain his equilibrium. Wilson is attempting to move on from the sudden and inexplicable suicide of his wife. His mother-in-law is there for him, but her sympathies turn quickly. He has an employer that seems to want to help him, and a workmate who wants him for herself. But nothing and no one can give Wilson solace; so, he seeks oblivion. It is not the usual alcohol or drugs. Wilson inhales fumes from gasoline cans and model airplane fuel and finds temporary salvation in the company of remote-control model enthusiasts. However, nothing that provides him relief really lasts.

Theater instructor Jerry starts an affair with Mary, and that starts a chain of events that affect their respective partners Terri and Barry and other characters in the film, creating a web of relationships.

In a very poor zone of New York, April Burns and her boyfriend, Bobby, are preparing to receive April's family for thanksgiving dinner. While Bobby tries to borrow a suit for himself, April realizes that her stove is broken. She tries desperately to find a neighbor that can let her cook the turkey, since she does not want to fail (again) with her family. Meanwhile, in a suburb of Pennsylvania, her dysfunctional family is preparing to travel to New York. While driving, the relationship between the Burns and their black-sheep April is disclosed through the conversations between her father Jim, her resented mother Joy, her brother, her sister and her grandmother.

'Jackie-O' is anxiously awaiting the visit of her brother home for Thanksgiving, but isn't expecting him to bring a friend. She's even more shocked to learn that this friend is his fiancée. It soon becomes clear that 'Jackie-O's obsession is nothing compared to her obsession with her brother, as it also becomes clear she isn't the only member of the family with problems...

Justin is a teenager boy, who has an oral obsession with his thumb. His mother seems to be a normal housekeeper, but she has her own obsessions as well, like a crush on a TV-star. The only person who's aware of Justin's problem is his father, manager in a store, but none of his advices seem to be working for Justin. The kid is signed up in a debate workshop, but the thing isn't going well, because he has his mind in a pretty classmate and, of course, in his thumb, affecting all the rest of his classes. So, Justin is a loner kid in the school, who prefers to lock himself in the bathroom and suck his thumb. Justin's dentist, a mystical-hippie person, will try to help to overcome his thumb problem, through the hypnosis. But the school's psychologist will diagnose Justin with the Attention Deficit Disorder, and will prescribe him some drugs. Suddenly, Justin's problem with his thumb will disappear, becoming an hyperactive genius, winning several debate contests and the admiration from his teacher. Nevertheless, more serious problems will come for Justin with his mother, his father and with a drug addiction.