Ian is a high school senior in suburban Chicago, plagued by being a virgin. Online he's inflated his resume, met Ms. Tasty, and agreed to drive to Knoxville where she promises sex. He steals his homophobic, macho brother's GTO, and, with his two best friends, Lance and Felicia, heads south. Every young woman who meets Lance, including Felicia, is attracted to him, as he practices his aptly learned "Pick-Up Artist" skills. Ian, on the other hand, is a decent guy who wouldn't mind if his friendship with Felicia became a romance. By the time they get to Knoxville, they have encountered a jealous boyfriend, a menacing hitchhiker, jail birds, carjackers, an Amish community, and Ian's better judgment.

A group of teenagers including Cindy Campbell and Bobby Prinze, accidentally hit a man when driving, and dispose of the body, but now they are being stalked by a very recognisable masked killer. The victim count increases, whilst Cindy must survive the carnage that has she has seen in so many films before.

Angelenos Doug Billings and Tracy Garner are about to get married. Two days before the wedding, the four men in the wedding party - Doug, Doug's two best buddies Phil Wenneck and Stu Price, and Tracy's brother Alan Garner - hop into Tracy's father's beloved Mercedes convertible for a 24-hour stag party to Las Vegas. Phil, a married high school teacher, has the same maturity level as his students when he's with his pals. Stu, a dentist, is worried about everything, especially what his controlling girlfriend Melissa thinks. Because she disapproves of traditional male bonding rituals, Stu has to lie to her about the stag, he telling her that they are going on a wine tasting tour in the Napa Valley. Regardless, he intends on eventually marrying her, against the advice and wishes of his friends. And Alan seems to be unaware of what are considered the social graces of the western world. The morning after their arrival in Las Vegas, they awaken in their hotel suite each with the worst hangover. None remembers what happened in the past twelve or so hours. The suite is in shambles. And certain things are in the suite that shouldn't be, and certain things that should be in the suite are missing. Probably the most important in the latter category is Doug. As Phil, Stu and Alan try to find Doug using only what little pieces of information they have at hand, they go on a journey of discovery of how certain things got into the suite and what happened to the missing items. However they are on a race for time as if they can't find Doug in the next few hours, they are going to have to explain to Tracy why they are not yet back in Los Angeles. And even worse, they may not find Doug at all before the wedding.

After being rejected from every college he applied, Bartleby Gaines decided to create a fictitious university, South Harmon Institute of Technology, with his friends, to fool their parents. But when their deception works too well and every other college rejects starts to apply to his school, B. must find a way to give the education and future his students and friends deserves, including his own, while trying to win the heart of the girl next door.

In Chicago, the art dealer Brooke Meyers feels not appreciated and neglected by her immature boyfriend Gary Grobowski, who is partner with his two brothers in a tourism business, and decides to break-up with him to make Gary miss her. Gary misunderstands her true intention, both follow the wrong advice of family members and friends, beginning a war of sexes with no winner.

Kassie (Jennifer Aniston) and Wally (Jason Bateman) are best friends. Being unlucky in love, Kassie has decided to have a child using artificial insemination. Wally doesn't like this idea, but he isn't capable of admitting to himself, let alone to Kassie, that he's in love with her. At Kassie's artificial insemination party, Wally gets very drunk and spies the sperm donor's sample in the bathroom. Wally was way too drunk to know what he did that night, and Kassie has moved away because she doesn't feel that New York City is a place to raise a child. Now 7 years later, Kassie has moved back with her son Sebastian. While she is looking to get Roland (the sperm donor) more involved in their lives, Wally can't help but notice the many striking similarities that he and Sebastian share.

Zack and Miri are two lifelong platonic friends who make an adult film to pay the rent of their apartment. With their friend Delaney, the couple set out for auditionees for their porn film, but in the process of filming, they realize they feel more for each other than they had before.

Noah is not your typical entertain-the-kids-no-matter-how-boring-it-is kind of sitter. He's reluctant to take a sitting gig; he'd rather, well, be doing anything else, especially if it involves slacking. When Noah is watching the neighbor's kid he gets a booty call from his girlfriend in the city. To hook up with her, Noah takes to the streets, but his urban adventure spins out of control as he finds himself on the run from a maniacal drug lord.

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