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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Eddie "Gonzo" Gilman is starting a revolution. When the wild-eyed rebel journalist is ousted from his prep school's newspaper by its über-popular editor, Eddie fronts an underground movement to give a voice to all the misfits, outcasts, and nerds. Soon the power of the press is in Eddie's hands... but will he use it wisely?

Two altar boys decide to play hooky after serving at a series of funerals.

Julie and Jason have been best friends for years with no romantic interest in each other. He sleeps with someone new every few days, and she's looking for Mr. Right. Now in their thirties, they notice that their friends seem to lose all their good qualities when they have children - child rearing and the spark of Eros don't seem to co-exist. So, they decide to have a child together, share in child rearing, but pursue their own romantic lives. Things go well until he meets Mary Jane and she meets Kurt. Both seem like perfect mates. What could go wrong?

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Sheltered by his grandparents, Luke, a young man with autism, is thrust into a world that doesn't expect anything from him. But Luke is on a quest for a job and true love. And he isn't taking no for an answer.

Violet and her two cohorts attempt to help their "less-fortunate" students at Seven Oaks College - primarily by running a Suicide Prevention Centre and offering their off-beat advice whenever they get a chance. Violet's newest rescue is transfer student, Lily, and Violet wants to teach her how to talk and dress properly, and how to select appropriate men to be interested in. Along their way in helping everybody at the college, the damsels teach the fraternity doofi to hit the books, they get their hearts broken, but then attempt to start an international dance craze.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Anna and Jacob fall instantly in love when they meet as students at an L.A. university. But Anna is British and when graduation approaches, Anna decides to stay and violate her student visa rather than returning to England. After a visit home, she is then unable to return to the United States. While fighting customs and immigration battles, Anna and Jacob must decide if their relationship is worth the distance and the hardship.

The relationship between two brothers, a father trying to connect with his sons and the young woman who gets between the three of them. The story begins when Caleb Sinclaire reluctantly picks up his brother Peter at college and brings him and his new girlfriend Emma home for the Thanksgiving holiday. Caleb, who recently broke up with his long-time girlfriend and is wary of relationships, warns Peter that Emma will end up hurting him, but he can't stop himself from being drawn to her. As Caleb's infatuation with Emma grows, he must decide whether to act on his feelings or protect his brother's first love.

About a recent college grad who returns home while she tries to figure out what to do with her life.

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who lives in the building and fakes her death to get the girl to let him in her apartment but holds a butcher knife between them. So it goes and he is no longer living in his car. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her to get out of the apartment, cooking, washing her hair. Both have demons and, as their stories become more clear, his addictive personality and her sex nausea may be on a collision course.

Do we ever get what we want? Brian sells mattresses in a warehouse store. His father and older brothers have material success; he wants a child. He's applied to adopt a baby from China. A man who appears homeless seems to be stalking Brian with violent intent. He meets Happy, the daughter of a rich, quirky customer. She doesn't stick to anything, but she and Brian hit it off, except for her vomiting when she learns about his adoption idea. He wants her to meet his family, and there's a call about the adoption. What will Happy do?

Lily and Alison face a life-changing event after they leave their Salton Sea home and follow the boys they meet back to Los Angeles.

Adam (Mark Ruffalo) has just reached the 5-year mark in his sex addiction sobriety with help from his sponsor Mike (Tim Robbins). New-comer Neil (Josh Gad) seeks out Adam's help hoping that he'll be his mentor, but Neil doesn't have the same maturity and continues to harass women at work, on the street, and on the subway. Adam has also just met Phoebe (Gwyneth Paltrow), who might be perfect for him, but Adam hasn't been in a relationship since he recognized his addiction to sex, and Phoebe doesn't date addicts. As Adam navigates the romantic relationship waters, Mike struggles connecting to his former drug-addicted son who has just returned home, and Neil develops a relationship with another woman in his sex addicts group, but a platonic friendship might be exactly what he needs.

Rachel is a quick-witted and lovable stay-at-home mom. Frustrated with the realities of preschool auctions, a lackluster sex life and career that's gone kaput, Rachel visits a strip club to spice up her marriage and meets McKenna, a stripper she adopts as her live-in nanny.

Craig is a high-school junior in the gifted program, infatuated with his best friend's girl. When he realizes he's suicidal, he checks himself into the psychiatric ward of a hospital, thinking they'll do an observation, help him, and send him home in time for school the next day. Once in, however, he must stay for a week; the juvenile ward is being renovated, so he's in with adults as well as a few youths. Bobby, a man with a young daughter, shows him around; Craig notices Noelle, about his age. He tries to keep his friends from finding out where he is. He draws, goes to therapy, sings, helps Bobby rehearse an interview. Is this the stuff of insight?

The night of their high school reunion, a group of friends realize they still haven't quite grown up in some ways.