Danny (Adam Sandler) must engage Katherine (Jennifer Aniston), his faithful assistant, to pretend to be his soon to be ex-wife. Danny must pretend that he is married, because he lied to his dream girl, Palmer (Brooklyn Decker) the most gorgeous woman in the world. To keep the woman he loves, covering up one lie soon turns into many lies.

Having given permission to male nurse Greg Focker to marry his daughter, ex-CIA man Jack Byrnes and his wife travel to Miami to Greg's parents, who this time around are Mr. and Mrs. Focker, who are as different from them as can be. As asked in the first movie, what sort of people name their son Gaylord M. Focker?

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