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Life really sucks for a group of gay and lesbian teenagers living in Los Angeles. Their parents kicked them out, they're broke and bored, their lovers cheat on them, they're harassed by gay-bashers. If things are going to be this way, maybe suicide isn't a bad idea; at least not in the mind of Andy, our major protagonist, who gives the film its title by describing himself as "totally fucked up."

In June, 1983, in Dutchess County, New York, Sebastian Cole joins his mother, step-father, and sister for dinner. Hank, Sebastian's step-father, drops a bomb: he announces he's changing sexes. Sebastian's sister splits immediately for California, and his mother takes him back to England. Jump ahead eight months, Sebastian is back in New York, knocking on Hank's door. Hank (now Henrietta, although all the surgeries aren't complete) takes Sebastian in and is his rock over the next few months of high school. Sebastian's "adventures" are mostly self-destructive.

In a small Minnesota town, the annual beauty pageant is being covered by a TV crew. Former winner Gladys Leeman wants to make sure her daughter follows in her footsteps. Explosions, falling lights, and trailer fires prove that. As the Leemans are the richest family in town the police are pretty relaxed about it all. Despite everything, main rival (but nice) Amber Atkins won't be stopped. There could well be more death and disappointment to come.

While helicopters overhead spray against a Medfly infestation a group of Los Angeles lives intersect, some casually, some to more lasting effect. Whilst they go out to concerts and jazz clubs and even have their pools cleaned, they also lie, drink, and cheat. Death itself seems never to be far away, even on a fishing trip.

Seventh-grade is no fun. Especially for Dawn Weiner when everyone at school calls you 'Dog-Face' or 'Wiener-Dog.' Not to mention if your older brother is 'King of the Nerds' and your younger sister is a cutesy ballerina who gets you in trouble but is your parents' favorite. And that's just the beginning--her life seems to be falling apart when she faces rejection from the older guy in her brother's band that she has a crush on, her parents want to tear down her 'Special People's Club' clubhouse, and her sister is abducted....

Successful Carolinian George Johnsten meets Chicago art gallery owner Madeleine at an electoral benefit art auction- love at first sight. Madeleine decides to meet a Southern original artist, so George seizes the opportunity to come along and present her to his North Carolina parents Eugene and Peg, drop-out brother Johny and his high-pregnant wife Ashley. Confronting the outsider soon opens a can of worms as emotions revive or emerge, like admiration and jealousy.

A Baltimore sandwich shop employee becomes an overnight sensation when a photographer's photos he's taken of his weird family become the latest rage in the art world.

After jointly winning a local Drag Queen pageant in New York City, Noxeema Jackson (Wesley Snipes) and Vida Boheme (Patrick Swayze) win the right and are given the round trip airfare to compete in the Drag Queen of America pageant in Hollywood, California. Noxeema sees herself as the next

Iris can best be described as a wallflower. She begins her first day as a temp for the nondescript Global Credit Association by waiting in a chair for two hours. This sets the scene for her (mis)adventures with the other "corporate orphans", Margaret, Paula and Jane. Led by Margaret, they find subtle ways to lessen the ennui of corporate oppression. The tension escalates when the new permanent hire, Cleo, enters the picture.

A 16 year old Louisiana girl moves in with her homosexual half-brother and immediately starts coming on to his sexual partner, finally forcing him into an affair in which she becomes pregnant. The whole affair blows into a scandal exposing her school teacher brother and the true parent of the child is called into question as it is revealed that there have been a series of lovers.

In New York City, Susan Weinblatt and Anne Munroe are longtime roommates and friends. Susan is a struggling photographer who wants to get out of the wedding and bar mitzvah racket, those jobs which she primarily gets through her friend, Rabbi Gold, to selling the photographs she wants to take, but she realizes that she has to pay the rent. Anne is an aspiring poet and academic who looks to Susan as her primary guidance. As they move into a new apartment, Anne drops the news that she will not be moving in as she is getting married to her boyfriend, Martin. This news is bittersweet for Susan who is somewhat happy for her friend, but isn't sure if she likes all that Martin now represents to her. Both Susan and Anne will have to make professional and personal adjustments to their new situations, especially in what it means for not having the other as a constant in each their lives. While Anne has a "Martin", Susan has no one currently to replace all that Anne has been in her life. So Susan goes through a series of new professional and personal relationships all in trying to find her way, while the two of them have to decide how and if to maintain their friendship in light of all these changes.

About to stay a summer internship, promising young medical student at MIT, Raymond's mother, Susan, breaks her leg. Housebound and immobile, his father, Tom, makes Raymond stay home and take care of her. Susan's a troubled woman, and along with Raymond's own emotional strains, it leads them to intimate physical contact, which Raymond finds uneasy. He soon meets a high school girl, Toni, but his ability to handle starting a relationship with her is difficult, due to the emotionally troubling recent events in his life.

Last Days of Disco loosely depicts the "last days" at a disco palace, where drugs, sex, and weirdness ran rampant. The story centers around a group of friends who frequent the disco and each other. All the characters are searching for something to make their lives more fulfilling. Some are searching for everlasting love and some just want something different. As the disco is closed, they all wonder: can disco ever really be dead?

A group of teenagers try to sort out their lives and emotions while bizarre experiences happen to each one, including alien abductions, bad acid trips, bisexual experiences, suicides, bizarre deaths, and a rape by a TV star. All of this happens before "the greatest party of the year".

Eliza D'Amico thinks her marriage to Louis is going great until she finds a mysterious love note to her husband. Concerned, she goes to her mother for advice. Eliza, her parents, her sister Jo, and Jo's boyfriend all pile into a station wagon to go into the city to confront Louis with the letter. On the way, the five explore their relationships with one another and meet many interesting people.

'Jackie-O' is anxiously awaiting the visit of her brother home for Thanksgiving, but isn't expecting him to bring a friend. She's even more shocked to learn that this friend is his fiancée. It soon becomes clear that 'Jackie-O's obsession is nothing compared to her obsession with her brother, as it also becomes clear she isn't the only member of the family with problems...

A quirky, out-of-of place worker at a crucifix factory in the Bible Belt invents a device he claims can show pictures of Heaven. Discouraged and confused by the inability of those around him to see anything but a screenful of static, he charismatically hijacks a bus of friendly elderly people in order to get media attention for his invention.

Although Roxy left town more than fifteen years ago, her memory has never faded. Her expected return starts to impact a number of lives, including that of her former partner Denton Webb. But it is Dinky, the adopted daughter of the Bossettis and ignored by most of her classmates as a strange loner, who may be most changed. She is convinced she is Roxie's secret child.