In 1986, In Brooklyn, New York, the dysfunctional family of pseudo intellectuals composed by the university professor Bernard and the prominent writer Joan split. Bernard is a selfish, cheap and jealous decadent writer that rationalizes every attitude in his family and life and does not accept "philistines" - people that do not read books or watch movies, while the unfaithful Joan is growing as a writer and has no problems with "philistines". Their sons, the teenager Walt and the boy Frank, feel the separation and take side: Walt stays with Bernard, and Frank with Joan, and both are affected with abnormal behaviors. Frank drinks booze and smears with sperm the books in the library and a locker in the dress room of his school. The messed-up and insecure Walt uses Roger Water's song "Hey You" in a festival as if it was of his own, and breaks up with his girlfriend Sophie. Meanwhile Joan has an affair with Frank's tennis teacher Ivan and Bernard with his student Lili.

A family weekend is fraught with emotional landmines for mercurial and sensitive Lynn (Barkin) as she arrives at her parents' Annapolis estate for the marriage of her estranged eldest son Dylan (Michael Nardelli), accompanied by her three younger children (Ezra Miller, Kate Bosworth, Daniel Yelsky). Lynn's hopes for a joyful reunion are crushed as her wry but troubled middle son Elliot (Ezra Miller) lobs verbal grenades at his mother and her relatives while daughter Alice (Kate Bosworth), a fights valiantly to keep her longtime demons under control. The weekend quickly unravels as Lynn demands to be heard by her aloof, disdainful mother (Ellen Burstyn), ailing, distant father (George Kennedy) and ever-judgmental sisters (Siobhan Fallon, Diana Scarwid), but most especially by her ex-husband Paul (Thomas Hayden Church) and his hot-tempered second wife Patty (Demi Moore). Confronted with the deeply painful, half-buried truths that have given rise to the family's primal web ofresentments and recriminations, Lynn struggles to maintain her equilibrium as her best attempts at reconciliation veer quickly off-course.

'Me and You and Everyone We Know' is a poetic and penetrating observation of how people struggle to connect with one another in an isolating contemporary world. Christine Jesperson is a lonely artist and "Eldercab" driver who uses her fantastical artistic visions to draw her aspirations and objects of desire closer to her. Richard Swersey, a newly-single shoe salesman and father of two boys, is prepared for amazing things to happen, but when he meets the captivating Christine, he panics. Life is not so oblique for Richard's six-year-old Robby, who is having a risqué Internet romance with a stranger, or Robby's 14-year-old brother Peter, who becomes the guinea pig for neighborhood girls practicing for their future of romance and marriage.

When three generations of a dysfunctional family gather in Rhode Island to bury the family patriarch, members of the Collins clan are at each other's throats in no time. Son Daniel is a secret porn actor, and daughter Lucy is a lesbian. Lucy totes along her lover Judy to the outrage of Lucy's aggressively neurotic sister Alice, whose hysterical overreaction to the pair's marriage plans ought to tell everyone something. Rounding out the delightful crowd are dim brother Skip, whose unfailingly rude twin sons offer caustic commentary on their elders' infantile predilections; matriarchal widow Charlotte, who becomes so justifiably distraught at the insanity of her children she tries to commit suicide; and Kate, a confused but comely college freshman who juggles preparation of the eulogy with internal debate over what to do with her childhood friend-turned-suitor, Ryan.

Seventeen year old Jason Slocumb, Jr. - Igby to most that know him - comes from east coast old money, the second son of self-absorbed and controlling Mimi Slocumb and medically-diagnosed schizophrenic Jason Slocum, Sr., the latter who has for several years been institutionalized in a Maryland psychiatric facility. While Igby's economics-studying Columbia-attending older brother Ollie Slocum has embraced and aspires to continue their wealthy life, Igby has rebelled against it, considering his brother a fascist (although he could soften that label to Republican). Because of Jason's situation, Mimi has largely left the role of male role model for Ollie and Igby to their godfather, D.H. Banes. Igby's rebellion has led to him being kicked out of one prep school after another, the latest, a military academy, from which Igby escapes before he can graduate. As such, Mimi and D.H. arrange for Igby to live in New York with Ollie for the summer while working for D.H. renovating some of his properties, before Mimi arranges for yet another strict school for the fall so that Igby can at least graduate. Igby is largely able to hide out for most of the summer with the help of Rachel, D.H.'s younger heroin addict mistress, and Sookie, a slightly older waitress with who he falls in love. An issue with Sookie and the aftermath of a joint mission with Ollie leads to Igby having a clearer picture of what his immediate future will look like.

Justin is a teenager boy, who has an oral obsession with his thumb. His mother seems to be a normal housekeeper, but she has her own obsessions as well, like a crush on a TV-star. The only person who's aware of Justin's problem is his father, manager in a store, but none of his advices seem to be working for Justin. The kid is signed up in a debate workshop, but the thing isn't going well, because he has his mind in a pretty classmate and, of course, in his thumb, affecting all the rest of his classes. So, Justin is a loner kid in the school, who prefers to lock himself in the bathroom and suck his thumb. Justin's dentist, a mystical-hippie person, will try to help to overcome his thumb problem, through the hypnosis. But the school's psychologist will diagnose Justin with the Attention Deficit Disorder, and will prescribe him some drugs. Suddenly, Justin's problem with his thumb will disappear, becoming an hyperactive genius, winning several debate contests and the admiration from his teacher. Nevertheless, more serious problems will come for Justin with his mother, his father and with a drug addiction.

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