On a flight from Los Angeles to New York, Oliver and Emily make a connection, only to decide that they are poorly suited to be together. Over the next seven years, however, they are reunited time and time again, they go from being acquaintances to close friends to ... lovers?

Reuben Feffer thinks he's found the love of his life but on his honeymoon he discovers her cheating on him with a scuba instructor. Reuben travels back home to get his life on track. On a night out with best pal, Sandy Lyle, Reuben discovers an old school friend, Polly Prince. Reuben feels a connection straight away, and tries constantly to get her to like him. But it's not going to be easy for Reuben, especially when he spends his days calculating risks, and when someone unexpected turns up.

In New York City, Thom is broke and jobless, illegally working as a taxi driver just to make some quick cash to try and pay his rent. Claire is a successful business-woman, but personally she's in shambles trying to recover from a bump in her marriage and then comes the phone call that her distant father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive. And so he does. The duo find themselves in Pennsylvania and make the rash decision to drive across the country. On the road to California, there are many detours, as the obstacles and secrets force them to learn about themselves and each other.

Tessa is seventeen and passionate about life. Diagnosed with a terminal illness, she determines to use every moment, compiling a catalogue of what a normal teenager would experience, including losing her virginity and taking drugs, With the help of her best friend, Zoey, she sets the list into motion. And while her parents and brother each deals with their fear of losing her in their own way, Tessa explores a whole new world, determined to live every day as intensely as possible. Falling in love with her new neighbor, Adam, wasn't on the list, but this proves to be the most exhilarating experience of them all.

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