In the high-tech gold rush of modern Silicon Valley, the people most qualified to succeed are the least capable of handling success. A comedy partially inspired by Mike Judge's own experiences as a Silicon Valley engineer in the late 1980s.

It's 1989, and 9-year-old Sheldon Cooper has skipped four grades to start high school along with his less-intellectual older brother. As he struggles to be understood by his family, classmates, and neighbors, his mother arms him with the best tool she has: reminding bullies that his dad is the football coach and his brother is on the team. His twin sister doesn't share his exceptional mind, but she is brilliant at reading people and has a much clearer vision of what life has in store for the young genius.

"Socially awkward high school student Otis may not have much experience in the lovemaking department, but he gets good guidance on the topic in his personal sex ed course -- living with mom Jean, who is a sex therapist. Being surrounded by manuals, videos and tediously open conversations about sex, Otis has become a reluctant expert on the subject. When his classmates learn about his home life, Otis decides to use his insider knowledge to improve his status at school, so he teams with whip-smart bad girl Maeve to set up an underground sex therapy clinic to deal with their classmates' problems. But through his analysis of teenage sexuality, Otis realizes that he may need some therapy of his own.

Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

The curious, adventure-seeking, fourth grade group of 10 year old boys, Stan, Kyle, Cartman, and Kenny, all join in in buffoonish adventures that sometimes evolve nothing. Sometimes something that was simple at the start, turns out to get out of control. Everything is odd in the small mountain town, South Park, and the boys always find something to do with it.

Captain Ray Holt takes over Brooklyn's 99th precinct, which includes Detective Jake Peralta, a talented but carefree detective who's used to doing whatever he wants. The other employees of the 99th precinct include Detective Amy Santiago, Jake's over achieving and competitive partner; Detective Rosa Diaz, a tough and kept to herself coworker; Detective Charles Boyle, Jake's best friend who also has crush on Rosa; Detective Sergeant Terry Jeffords, who was recently taken off the field after the birth of his twin girls; and Gina Linetti, the precinct's sarcastic administrator.

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