Bloomington, Minnesota, 1967: Jewish physics lecturer Larry Gopnik is a serious and a very put-upon man. His daughter is stealing from him to save up for a nose job, his pot-head son, who gets stoned at his own bar-mitzvah, only wants him round to fix the TV aerial and his useless brother Arthur is an unwelcome house guest. But both Arthur and Larry get turfed out into a motel when Larry's wife Judy, who wants a divorce, moves her lover, Sy, into the house and even after Sy's death in a car crash they are still there. With lawyers' bills mounting for his divorce, Arthur's criminal court appearances and a land feud with a neighbour Larry is tempted to take the bribe offered by a student to give him an illegal exam pass mark. And the rabbis he visits for advice only dole out platitudes. Still God moves in mysterious - and not always pleasant - ways, as Larry and his family will find out.

Still untarnished by the false promises of the rapacious film industry, the wide-eyed actress, Betty, sets foot on bustling, sun-kissed Hollywood. Brimming with hope, and eager to spread her wings and prove her worth, Betty moves in Aunt Ruth's expensive apartment, unbeknownst to her, however, that fate has other plans in store for her, setting the stage for life-altering experiences with the unexpected, the indecipherable, and the unknown. Now, in the centre of an elaborate labyrinth of half-truths, faded memories, unrequited loves, and dangerous encounters with the city's ugly face lies a strange key to a mysterious keyhole, an even stranger indigo-blue cube, the young director, Adam, and one cryptic woman: the amnesiac brunette and devilishly seductive car-crash survivor, Rita. But, time flies and Rita's opaque past demands answers. After all, both women deserve the truth. What is the secret of the serpentine, dream-crushing Mulholland Drive?

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