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Detective Catherine Chandler (Kristin Kreuk), shaken to the core over the fact that everything she thought she knew about her life has been a lie, is determined to get answers to the secrets that have been revealed about her family. Cat must also try to navigate her evolving relationship with handsome doctor Vincent Keller (Jay Ryan), who struggles with becoming a terrifying beast when he is enraged, unable to control his super-strength and heightened senses. Cat and Vincent continue to grapple with the desire to be a normal couple while trying to keep a low profile in order to stay one step ahead of the mysterious organization known as Muirfield, now on the hunt for both of them.

A young CIA operative/trainee, Annie Walker, is sent into the field to work for the DPD (Domestic Protection Division). Auggie Anderson is a blind tech operative, and is Walker's guide in her new life in the CIA. Walker's cover story is that she works at the Smithsonian Museum.

People all over the U.S and the world start to realize they have special abilities, like telekinesis, healing abilities, flying powers, time travel, invisibility, and the ability to absorb other's abilities. One man, known as Sylar, wants to gain all the power of these "heroes" so he can be the most powerful and evolved human of all, and stops at nothing to gruesomely kill these people. In order to protect themselves from him, these people must help one another before Sylar can destroy them all, while they each deal with problems of their own.

John Winchester raised his two sons Sam and Dean to hunt and kill all things that go "bump in the night" after his wife Mary was murdered by an evil supernatural being when the boys were little. 22 years later the brothers set out on a journey, fighting evil along the way, to find their recently-missing father; when they finally do he reveals he knows what demon killed their mother and has found a way to track and kill it. Meanwhile, Sam develops frightening abilities such as seeing visions of people dying before it actually happens. These visions are somehow connected to the demon that murdered his mother and its mysterious plans that seem to be all about Sam. When their father dies striking a deal with that very same demon, the brothers determine to finish his crusade. But disturbing revelations about Sam's part in the demon's apocalyptic plan are presented when John's dying last words to Dean are revealed.

Portland detective, Nick Burkhardt, has seen some gruesome crime scenes, but nothing prepares him for the strange visions he begins seeing: seemingly regular people momentarily transforming into hideous monsters. A visit from his only living relative reveals the truth. Nick has inherited the ability to see supernatural creatures, and as a "Grimm," he is tasked with keeping the balance between mankind and the mythological. A reformed "Big Bad Wolf" becomes his greatest (and also reluctant) ally and confidant. It's not long before his work as a policeman leads Nick to the criminals he once thought were only found in fairy tales.

For Emma Swan, life has been anything but a happy ending. But when she's reunited with Henry - the son she gave up for adoption ten years ago - on the night of her 28th birthday, everything changes. The now 10-year-old Henry is in desperate need of Emma's help because he believes from reading a book of fairy-tales that she's the daughter of Snow White and Prince Charming - who sent her away from the Enchanted Forest to be protected from a curse that was enacted by the Evil Queen. Emma initially refuses to believe a word of Henry's story but soon finds that his hometown of Storybrooke, Maine is more than it seems. Because it's in Storybrooke that all of the classic characters we know are frozen in time with no memories of their former selves - except for the Evil Queen, who is Storybrooke's mayor and Henry's adoptive mother Regina Mills. Now, as the epic "Final Battle" for the future of both worlds approaches, Emma will have to accept her destiny and uncover the mystery behind a place where fairy-tales are to be believed.

Lucifer Morningstar, bored from his sulking life in hell, comes to live in Los Angeles. While there, he helps humanity with its miseries through his experience and telepathic abilities to bring people's deepest desires and thoughts out of them. While meeting with a Detective in his nightclub (Lux), a shootout involving him and the Detective leads him to become an LAPD consultant who tries to punish people for their crimes through law and justice.

Based on the real life of Walter O'Brien, a genius with an IQ of 197. Walter is asked by Homeland Security to put together a special group of gifted individuals to troubleshoot the most difficult problems that the US & the world may encounter.

A Seattle family takes in an amnesiac teen (Dallas), whom they eventually learn has mysterious powers and psychic abilities, the result of a secret human cloning experiment conducted years earlier. The family helps teach Kyle human behaviors such as anger, joy and love, and guards him against forces who seek to use Kyle for their own nefarious purposes.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

The story of several young people from around the world who represent the next stage in human evolution, possessing special powers, including the ability to teleport and communicate with each other telepathically. Together they work to defeat the forces of evil.

Richard "Rick" Castle is a millionaire playboy who recently killed off his main character when a serial killer starts killing people like he does in his books. He teams up with New York police detective Kate Beckett to solve the case. He finds inspiration in Detective Beckett and starts shadowing her for his next book.

When she was a deeply troubled teenager, Nikita was rescued from death row by a secret U.S. agency known only as Division, who faked her execution and told her she was being given a second chance to start a new life and serve her country. What they didn't tell her was that she was being trained as a spy and assassin. Throughout her grueling training at Division, Nikita never lost her humanity, even falling in love with a civilian. When her fiancé was murdered, Nikita realized she had been betrayed and her dreams shattered by the only people she thought she could trust, so she did what no one else before her had been able to do: she escaped. Now, after three years in hiding, Nikita is seeking retribution and making it clear to her former bosses that she will stop at nothing to expose and destroy their covert operation.

After the Battle of New York, the world has changed. It now knows not only about the Avengers, but also the powerful menaces that require those superheroes and more to face them. In response, Phil Coulson of the Strategic Homeland Intervention, Enforcement and Logistics Division assembles an elite covert team to find and deal with these threats wherever they are found. With a world rapidly becoming more bizarre and dangerous than ever before as the supervillains arise, these agents of S.H.I.E.L.D. are ready to take them on.

Medical student Liv Moore gets invited in a party that turns into a macabre zombie arena. Liv wakes up from the dead and becomes a zombie. To maintain her humanity she must eat human brains so she starts to work in the coroner's officer to access brains. Eating a brain gives her that person's traits and memories, so she helps Detective Clive Babineaux solve the murder as a psychic.

The Powells are a typical American family living in Pacific Bay, California, whose members gain special powers after their plane crashes in the Amazon.

Scott McCall was just another kid in high school. Until, one night his best friend Stiles brings him to the woods, to look for a dead body, and Scott is bitten by a werewolf. Being a werewolf came with its perks- stronger, faster, new star in the lacrosse team, popularity- but also made it hard to control his anger. Scott has also fallen for the new girl in town, Allison, whose dad is trying to hunt and kill Scott. Scott now has to try and balance his out of control life, figure out how to control his new powers, try not to be killed by the alpha that bit him, and protect Allison- and keep her from finding out his big secret.

After a meteor shower bursts from the heavens, raining destruction on the unsuspecting citizens of Smallville, years pass, and the healing process leaves the town's inhabitants with scars and secrets. From the ashes of tragedy, a popular yet awkward teen attempts to decipher the meaning of his life and his clouded past. As he struggles with the transition from boyhood to adulthood, Clark finds that his strength and strange abilities set him uncomfortably apart from his peers.