In the late 1960s, just for a lark, graduate student Eddie Jessup, known for being unconventional, brilliant and slightly mad, conducts experiments with an isolation chamber, using himself as the subject. His experiences in the chamber cause him to hallucinate, much of the imagery being religious-based although he's not religious. Seven years later, he is a respected full professor in the Harvard Medical School. Believing he has lost his edge and fallen into an unwanted state of respectability, Eddie decides to resume his work with sensory deprivation, this time using hallucinogens, specifically untested ones used in mystical Mexican rituals, to enhance the isolation-take experience. After initial tests, he claims he entered an alternate physical and mental state. Although unbelieving of Eddie's claims, his colleagues Arthur Rosenberg and Mason Parrish, as well as Eddie's wife Emily, herself a respected academic, are concerned for Eddie's well being. However, if Eddie's claims are indeed true, he could do irreparable harm to himself and others around him, especially if his altered states are uncontrollable.

Thomas Jerome Newton is a humanoid alien who comes to Earth to get water for his dying planet. He starts a high technology company to get the billions of dollars he needs to build a return spacecraft, and meets Mary-Lou, a girl who falls in love with him. He does not count on the greed and ruthlessness of business here on Earth, however.

1976 British science fiction film by Nicolas Roeg

In a totalitarian society in a near future, the undercover detective Bob Arctor is working with a small time group of drug users trying to reach the big distributors of a brain-damaging drug called Substance D. His assignment is promoted by the recovery center New Path Corporation, and when Bob begins to lose his own identity and have schizophrenic behavior, he is submitted to tests to check his mental conditions.

College student Jeffrey Beaumont returns to his idyllic hometown of Lumberton to manage his father's hardware store while his father is hospitalized. Walking though a grassy meadow near the family home, Jeffrey finds a severed human ear. After an initial investigation, lead police Detective John Williams advises Jeffrey not to speak to anyone about the case as they investigate further. Detective Williams also tells Jeffrey that he cannot divulge any information about what the police know. Detective Williams' high school aged daughter, Sandy Williams, tells Jeffrey what she knows about the case from overhearing her father's private conversations on the matter: that it has to do with a nightclub singer named Dorothy Vallens, who lives in an older apartment building near the Beaumont home. His curiosity getting the better of him, Jeffrey, with Sandy's help, decides to find out more about the woman at the center of the case by breaking into Dorothy's apartment while he knows she's at work. What Jeffrey finds is a world unfamiliar to him, one that he doesn't truly understand but one that he is unable to deny the lure of despite the inherent dangers of being associated with a possible murder. Still, he is torn between this world and the prospect of a relationship with Sandy, the two who are falling for each other, despite Sandy already being in a relationship with Mike, the school's star football player.

Max Renn is the President of Channel 83 Civic-TV, a small television station on the UHF dial. He defends his programming of largely X-rated shows - which depict graphic sex and extreme violence - as a pure matter of economic survival as a small station. Behind closed doors in specific company, he would admit that he enjoys such programming, but as President will stay away from associated activities that may be dangerous for him in its purchase. His current girlfriend, radio personality Nicki Brand, who he met on a television talk show, is sexually aroused by light mutilation on her person, that despite or because her radio show is like an open air crisis hotline. On that same talk show, the other guest via video feed was Professor Brian O'Blivion - solely his stage name - who believes that television and video broadcasts will one day overtake the world as reality, which may make Max's programming in combination more dangerous. In Max's search for the next big thing in like programming already on Channel 83, Harlan, his pirater who scans satellite signals, illegally obtains a satellite feed of something called Videodrome, which depicts continual sexualized torture and murder with no storyline of which to speak. The background behind Videodrome is unknown, but believing it is that big thing for which he is looking, Max is determined to find the producers so that he can purchase it for his station. He is concerned for Nicki if she goes ahead against his warnings in wanting to appear on Videodrome, however it does not lessen his desire to purchase it. If Max in turn does not heed the warning of Masha, one of his long time show suppliers, based on what little she discovers about it, Max may discover that Videodrome is just the next but destructive step in O'Blivion's prognostication.

Sam Lowry (Jonathan Pryce) is a harried technocrat in a futuristic society that is needlessly convoluted and inefficient. He dreams of a life where he can fly away from technology and overpowering bureaucracy, and spend eternity with the woman of his dreams. While trying to rectify the wrongful arrest of one Harry Buttle (Brian Miller), Lowry meets the woman he is always chasing in his dreams, Jill Layton (Kim Greist). Meanwhile, the bureaucracy has fingered him responsible for a rash of terrorist bombings, and Sam and Jill's lives are put in danger.

Puppeteer Craig Schwartz and animal lover and pet store clerk Lotte Schwartz are just going through the motions of their marriage. Despite not being able to earn a living solely through puppeteering, Craig loves his profession as it allows him to inhabit the skin of others. He begins to take the ability to inhabit the skin of others to the next level when he is forced to take a job as a file clerk for the off-kilter LesterCorp, located on the five-foot tall 7½ floor of a Manhattan office building. Behind one of the filing cabinets in his work area, Craig finds a hidden door which he learns is a portal into the mind of

In NYC's Chinatown, recluse math genius Max (Sean Gullette) believes "everything can be understood in terms of numbers," and he looks for a pattern in the system as he suffers headaches, plays Go with former teacher Sol Robeson (Mark Margolis), and fools around with an advanced computer system he's built in his apartment. Both a Wall Street company and a Hasidic sect take an interest in his work, but he's distracted by blackout attacks, hallucinations, and paranoid delusions..

Bill struggles to put together his shattered psyche, in this new feature film version of Don Hertzfeldt's animated short film trilogy.

2012 animated feature film directed by Don Hertzfeldt

A Christlike figure wanders through bizarre, grotesque scenarios filled with religious and sacrilegious imagery. He meets a mystical guide who introduces him to seven wealthy and powerful people, each representing a planet in the Solar system. These seven, along with the protagonist, the guide and the guide's assistant, divest themselves of their worldly goods and form a group of nine who will seek the Holy Mountain, in order to displace the gods who live there and become immortal.

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