Two FBI agents, fighting the departmental stigma of backroom boys - those who try to complicate the status quo of simple Means, Motive, Opportunity (MMO) of crime-solving with academics - work to develop an innovative investigative field incorporating psychology, anthropology and sociology as a method to reveal the motive. They acknowledge classic crime-solving - MMO - as no longer sufficient because criminality is becoming more complicated as Motive graduates from need and greed to inexplicable and irrational reasons. They theorize applying deeper psychological evaluation will posit new questions. Simply, asking Why will lead to the Who. This series focuses on the development by two men, two agents, of a new criminal field and does so through story lines of visiting the sociopathic mind.

Eve is a bored, whip-smart security services operative whose desk-bound job doesn't fulfill her fantasies of being a spy. Villanelle is a talented killer, who clings to the luxuries her violent job affords her. These two fierce women, equally obsessed with each other, will go head to head in an epic game of cat and mouse, toppling the typical spy-action thriller.

In the dystopian world of 2027 London, humans have been incapable of reproducing for 18 year for an unknown reason, meaning the imminent extinction of the species. Britain is the one remaining civilized society on the planet, which has resulted in people wanting to migrate there, so it has become a police state to handle the immigrants, who are placed into refugee camps. Lowly government bureaucrat Theo Faron, once an activist, is approached by the Fishes, deemed a terrorist group, led by his ex-wife Julian Taylor, whom he hasn't seen in almost 20 years, since their marriage disintegrated after their infant son Dylan's death during the 2008 flu pandemic. Although the Fishes did use terrorist means in their on-going revolution against the state in the fight for immigrant rights, Julian vows that they now garner support solely by speaking to the people, and she wants Theo to use his connections to get transit papers for a young immigrant woman named Kee who needs to get to the coast. Although initially reluctant to do it because of the difficulty, Theo is able to grant Julian this favor, however with the change that he now needs to accompany Kee on her journey. As Theo and Kee progress on that journey, Theo learns more and more about what's going on, including the reason that Kee needs to get to the coast, the fact that no one in the group knows if their end destination even exists, and that his and Kee's lives are in greater danger than he believed when they started the journey. But Theo's sole mission becomes to help Kee at any cost for the survival of the species.

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