The Byrdes and their teenage kids, Charlotte and Jonah, are, for all intents and purposes, an ordinary family with ordinary lives. Except for the job of Marty, a Chicago financial advisor who also serves as the top money launderer for the second largest drug cartel in Mexico. When things go awry, Marty must uproot his family from the skyscrapers of Chicago and relocate to the lazy lake region of the Missouri Ozarks.

Centers on Nicholas (Josh Thomas), a typical 25-year-old returning home to his single dad and two teenage half-sisters who is not particularly helpful in raising his siblings, one of whom is autistic. However, when their dad becomes terminally ill, the girls have to cope with not only a devastating loss but also the realization that Nicholas is the one who will have to hold it all together.

The Roy family is known for controlling the biggest media and entertainment company in the world. However, their world changes when their father steps down from the company.

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