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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Eddie "Gonzo" Gilman is starting a revolution. When the wild-eyed rebel journalist is ousted from his prep school's newspaper by its über-popular editor, Eddie fronts an underground movement to give a voice to all the misfits, outcasts, and nerds. Soon the power of the press is in Eddie's hands... but will he use it wisely?

Julie and Jason have been best friends for years with no romantic interest in each other. He sleeps with someone new every few days, and she's looking for Mr. Right. Now in their thirties, they notice that their friends seem to lose all their good qualities when they have children - child rearing and the spark of Eros don't seem to co-exist. So, they decide to have a child together, share in child rearing, but pursue their own romantic lives. Things go well until he meets Mary Jane and she meets Kurt. Both seem like perfect mates. What could go wrong?

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Violet and her two cohorts attempt to help their "less-fortunate" students at Seven Oaks College - primarily by running a Suicide Prevention Centre and offering their off-beat advice whenever they get a chance. Violet's newest rescue is transfer student, Lily, and Violet wants to teach her how to talk and dress properly, and how to select appropriate men to be interested in. Along their way in helping everybody at the college, the damsels teach the fraternity doofi to hit the books, they get their hearts broken, but then attempt to start an international dance craze.

Josh and Emily are in a relationship, but he can be inattentive and unromantic and she can shift her focus from small things to emotional issues in a moment. He invites her to drive from New York City to somewhere in Virginia to pick up a chair that he's bought on eBay for his father's birthday. On the way, he stops at his brother Rhett's, outside Philly, and invites him along. Josh tries to save money at a motel, has to negotiate with the seller of the chair and with an upholsterer, and faces tough questions from Emily. He calls her "Dude," he's moody, and it looks as if the relationship will end soon. Is there more than meets the eye here? How do people decide?

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

Hollywood actor Johnny Marco, nested in his luxury hotel of choice, is a stimulated man. Drinking, parties and women keep a creeping boredom under wraps in between jobs. He is the occasional father of a bright girl, Cleo, who may be spoiled but doesn't act it. When Cleo's mother drops her off and leaves town, Johnny brings her along for the ride, but can he fit an 11-year-old girl into his privileged lifestyle?

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who lives in the building and fakes her death to get the girl to let him in her apartment but holds a butcher knife between them. So it goes and he is no longer living in his car. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her to get out of the apartment, cooking, washing her hair. Both have demons and, as their stories become more clear, his addictive personality and her sex nausea may be on a collision course.

For aspiring comedian Donna Stern, everyday life as a female twenty-something provides ample material for her relatable brand of humor. On stage, Donna is unapologetically herself, joking about topics as intimate as her sex life and as crude as her day-old underwear. But when Donna winds up unexpectedly pregnant after a one-night stand, she is forced to face the uncomfortable realities of independent womanhood for the first time. Donna's drunken hookup - and epic lapse in prophylactic judgment - turns out to be the beginning of an unplanned journey of self-discovery and empowerment.

Do we ever get what we want? Brian sells mattresses in a warehouse store. His father and older brothers have material success; he wants a child. He's applied to adopt a baby from China. A man who appears homeless seems to be stalking Brian with violent intent. He meets Happy, the daughter of a rich, quirky customer. She doesn't stick to anything, but she and Brian hit it off, except for her vomiting when she learns about his adoption idea. He wants her to meet his family, and there's a call about the adoption. What will Happy do?

A burgeoning stand-up comedian struggles with the stress of a stalled career, a stale relationship, and the wild spurts of severe sleepwalking he is desperate to ignore.

Adam (Mark Ruffalo) has just reached the 5-year mark in his sex addiction sobriety with help from his sponsor Mike (Tim Robbins). New-comer Neil (Josh Gad) seeks out Adam's help hoping that he'll be his mentor, but Neil doesn't have the same maturity and continues to harass women at work, on the street, and on the subway. Adam has also just met Phoebe (Gwyneth Paltrow), who might be perfect for him, but Adam hasn't been in a relationship since he recognized his addiction to sex, and Phoebe doesn't date addicts. As Adam navigates the romantic relationship waters, Mike struggles connecting to his former drug-addicted son who has just returned home, and Neil develops a relationship with another woman in his sex addicts group, but a platonic friendship might be exactly what he needs.

Nora Wilder is freaking out. Everyone around her is either in a relationship, married, or has children. Nora is in her thirties, alone with job she's outgrown and a mother who constantly reminds her of it all. Not to mention her best friend Audrey's "perfect marriage". But after a series of disastrous dates, Nora unexpectedly meets Julien, a quirky Frenchman who opens her eyes to a lot more than love.

Rachel is a quick-witted and lovable stay-at-home mom. Frustrated with the realities of preschool auctions, a lackluster sex life and career that's gone kaput, Rachel visits a strip club to spice up her marriage and meets McKenna, a stripper she adopts as her live-in nanny.

We like Florence: she's considerate, sweet, pretty, and terrific with kids and dogs. She's twenty-five, personal assistant to an L.A. family that's off on vacation. Her boss's brother comes in from New York City, fresh from a stay at an asylum, to take care of the house. He's Roger, a forty-year-old carpenter, gone from L.A. for fifteen years. He arrives, doesn't drive, and needs Florence's help, especially with the family's dog. He's also connecting with former band-mates - two men and one woman with whom he has a history. He over-analyzes, has a short fuse, and doesn't laugh at himself easily. As he navigates past and present, he's his own saboteur. And what of Florence? is Roger one more responsibility for her or something else?

Daryl and Zoe have been together for four years and boredom begins to be felt; their bond, however, is so deep that it is almost an addiction they cannot do without. They therefore decide to plan their separation, establishing a relationship strategy according to which they will be able to see each other on alternate days and meet other people, experiencing the open couple model firsthand. Parents are also involved in this attempt, giving advice, but above all asking the same questions as their children.

Iris invites her friend Jack, who's mourning his brother's death, to her father's cottage for some alone time to recuperate, but they discover that Iris' sister Hannah is already there recovering from a recent break-up. One whole bottle of tequila later, Jack and Hannah wake up to find Iris at the door. All three have secrets they're trying to keep and feelings they're trying to sort out.