With Special Guest Lauren Lapkus is an improvisational comedy podcast hosted by Lauren Lapkus where each week the guest is the host. Lapkus takes the guest role in each episode, allowing her guest host to decide the podcast's title, subject matter, and Lapkus's character. Regardless of the host, each episode of the podcast ends with a segment called "Help Me Rhonda", where Lapkus's recurring character Traci Reardon gives advice to her Twitter followers.

In 2012, Lapkus began making guest appearances on several podcasts on the Earwolf network, such as Comedy Bang! Bang! and improv4humans. In 2014, Earwolf approached Lapkus to host her own show and they signed her to a two-year contract. She explained, "Eventually they came to me and said, 'Do you want to do a podcast and what would you do?' I think it was just part of becoming a part of the family slowly over time".

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