Protagonist Alex DeLarge is an "ultraviolent" youth in futuristic Britain. As with all luck, his eventually runs out and he's arrested and convicted of murder. While in prison, Alex learns of an experimental program in which convicts are programmed to detest violence. If he goes through the program, his sentence will be reduced and he will be back on the streets sooner than expected. But Alex's ordeals are far from over once he hits the streets of Britain..

It's a post-apocalyptic world, several years after whatever the cataclysmic event, which has in turn caused frequent quakes as further potential hazards. The world is gray and getting quickly grayer as more and more things die off. A man and his pre-teen son, who was born after the apocalypse, are currently on the road, their plan to walk to the coast and head south where the man hopes there will be a more hospitable environment in which to live. The man has taught his son that they are the "good people" who have fire in their hearts, which in combination largely means that they will not resort to cannibalism to survive. The man owns a pistol with two bullets remaining, which he will use for murder/suicide of him and his son if he feels that that is a better fate for them than life in the alternative. Food and fuel are for what everyone is looking. The man has taught his son to be suspect of everyone that they may meet, these strangers who, out of desperation, may not only try to steal what they have managed to scavenge for their own survival, but may kill them as food. Although life with his father in this world is all the boy has known, he may come to his own thoughts as to what it means holistically to be one of the good or one of the bad. Meanwhile, the man occasionally has thoughts to happier times with his wife/the boy's mother before the apocalypse, as well as not as happy times with her after the apocalypse and the reason she is no longer with them.

Sara Goldfarb (Ellen Burstyn) is a retired widow, living in a small apartment. She spends most of her time watching TV, especially a particular self-help show. She has delusions of rising above her current dull existence by being a guest on that show. Her son, Harry (Jared Leto) is a junkie but along with his friend Tyrone (Marlon Wayans) has visions of making it big by becoming a drug dealer. Harry's girlfriend Marion (Jennifer Connelly) could be fashion designer or artist but is swept along in Harry's drug-centric world. Meanwhile Sara has developed an addiction of her own. She desperately wants to lose weight and so goes on a crash course involving popping pills, pills which turn out to be very addictive and harmful to her mental state.

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