The series follows the life of anti-social, pain killer addict, witty and arrogant medical doctor Gregory House (Hugh Laurie) with only half a muscle in his right leg. He and his team of medical doctors try to cure complex and rare diseases from very ill ordinary people in the United States of America.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital surgical unit. Alone in the world and unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

While running from a drug deal gone bad, brilliant young college-dropout Mike Ross slips into a job interview with one of New York City's best legal closers, Harvey Specter. Tired of cookie-cutter law school grads, Harvey takes a gamble by hiring Mike on the spot after recognizing his raw talent and photographic memory. Mike and Harvey are a winning team. Although Mike is a genius, he still has a lot to learn about the law; and while Harvey might seem like an emotionless, cold-blooded shark, Mike's sympathy and concern for their cases and clients will help remind Harvey why he went into law in the first place. Mike's other allies in the office include the firm's best paralegal Rachel and Harvey's no-nonsense assistant Donna. Proving to be an irrepressible duo and invaluable to the practice, Mike and Harvey must keep their secret from everyone including managing partner Jessica and Harvey's arch nemesis Louis, who seems intent on making Mike's life as difficult as possible.

The Byrdes and their teenage kids, Charlotte and Jonah, are, for all intents and purposes, an ordinary family with ordinary lives. Except for the job of Marty, a Chicago financial advisor who also serves as the top money launderer for the second largest drug cartel in Mexico. When things go awry, Marty must uproot his family from the skyscrapers of Chicago and relocate to the lazy lake region of the Missouri Ozarks.

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