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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Twenty-something native Vermonter Mirabelle Buttersfield, having recently graduated from college, is finding her new life in Los Angeles not quite what she was expecting or hoping. An aspiring artist, she is barely eking out a living working as a clerk at the women's evening gloves counter at Saks Fifth Avenue in Beverly Hills and thus she can barely make the payments on her massive student loans. She treats her job with a certain distance, often daydreaming as she watches the life of the rich as they shop at the store. She has made no friends, including from among her Saks colleagues, and thus lives a solitary existence, which does not assist in her dealing with her chronic clinical depression. So it is with some surprise that two men with a romantic interest in her enter her life almost simultaneously. The first is poor slacker Jeremy, who works as an amplifier salesman/font designer. Mirabelle continues dating Jeremy as only a relief to her solitary life, as Jeremy doesn't seem to understand how to treat her in the way she wants. Shortly after meeting Jeremy, she meets the second, wealthy fifty-something Ray Porter, who is the antithesis of Jeremy in almost every respect, including the fact that Ray is unwilling or unable to commit to Mirabelle, about which he is up front to her. To Mirabelle, that lack of commitment from Ray seems to be in name only, and as such she increasingly sees Ray as her boyfriend. Mirabelle has to decide if a long term future is either in the cards with Jeremy or Ray, which is made all the more complicated by an action by Jeremy to an off the cuff comment that she makes to him.

Friendship, love, and coming of age in New York City, summer of 1994. Luke Shapiro has just graduated from high school, sells marijuana, and trades pot for therapy from a psychologist, Dr. Jeffrey Squires. Luke is attracted to a classmate, Stephanie, who's out of his league and Squires' step-daughter. By July, he's hanging out with Stephanie, taking her on his rounds selling pot out of an ice-cream pushcart. Then things take a turn. In the background, Squires and his wife as well as Luke's parents are having their troubles.

Smart-but-ineffectual journalist Dan "We use euphemisms!" cannot decide between his girlfriend, loving-but-clingy waitress Alice, or his lover cold-but-intellectual photographer Anna; herself indecisive between Dan and honest-but-thuggish "You're bloody gorgeous!" doctor Larry. The film puts the four leading characters in a box and strips them apart.

After it looks as if she's left his life for good this time, Tom Hansen reflects back on the just over one year that he knew Summer Finn. For Tom, it was love at first sight when she walked into the greeting card company where he worked, she the new administrative assistant. Soon, Tom knew that Summer was the woman with whom he wanted to spend the rest of his life. Although Summer did not believe in relationships or boyfriends - in her assertion, real life will always ultimately get in the way - Tom and Summer became more than just friends. Through the trials and tribulations of Tom and Summer's so-called relationship, Tom could always count on the advice of his two best friends, McKenzie and Paul. However, it is Tom's adolescent sister, Rachel, who is his voice of reason. After all is said and done, Tom is the one who ultimately has to make the choice to listen or not.

A man about forty years of age tells the story from when he was a teenager in upscale suburban Detroit of his and three of his friends' fascination with the mysterious and doomed Lisbon sisters. In 1974, the sisters were seventeen year old Therese, sixteen year old Mary, fifteen year old Bonnie, fourteen year old Lux, and thirteen year old Cecilia. Their fascination still remains as they try to piece together the entire story. The sisters were mysteries if only because of having a strict and overprotective upbringing by their father, who taught math at the girls' private co-ed school, and overly devout Catholic mother, who largely dictated the household rules. The story focuses primarily on two incidents and the resulting situations on the girls' lives. The first was an action by Cecilia to deal with her emotions over her life. And the second was the relationship between Lux - the sister who pushed the boundaries of the household rules most overtly in doing what most teenagers want to do - and Trip Fontaine, he who could have any girl he wanted but wanting solely Lux.

Dean Pereira and Cindy Heller Pereira are a young, working class married couple - Dean currently working as a painter, and Cindy working as a nurse in a medical clinic - with a young daughter named Frankie. Despite their relatively tender ages, they are both ravaged by the life they've eked out together and by the experiences they've had leading into their marriage. Dean, a high school drop out, comes from a broken home, where he never really had a mother figure. He never saw himself getting married or having a family despite falling in love at first sight with Cindy. He doesn't have any professional ambition beyond his current work - which he enjoys since he feels he can knock off a beer at 8 o'clock in the morning without it affecting his work - although Cindy believes he has so much more potential in life. Cindy also comes from a dysfunctional family, with her own mother and father not setting an example of a harmonious married or family life. One of her previous serious relationships was with Bobby Ontario, that relationship which has a profound affect on many aspects of her marriage to Dean. Dean and Cindy head off on an overnight getaway together without Frankie, the getaway which may provide a clearer picture if their marriage can survive its many issues.

Hollywood actor Johnny Marco, nested in his luxury hotel of choice, is a stimulated man. Drinking, parties and women keep a creeping boredom under wraps in between jobs. He is the occasional father of a bright girl, Cleo, who may be spoiled but doesn't act it. When Cleo's mother drops her off and leaves town, Johnny brings her along for the ride, but can he fit an 11-year-old girl into his privileged lifestyle?

Paris, je t'aime is about the plurality of cinema in one mythic location: Paris, the City of Love. Twenty filmmakers have five minutes each; the audience must weave a single narrative out of twenty moments. The 20 moments are fused by transitional interstitial sequences and also via the introduction and epilogue. Each transition begins with the last shot of the previous film and ends with the first shot of the following film, extending the enchantment and the emotion of the previous segment, preparing the audience for a surprise, and providing a cohesive atmosphere. There's a reappearing mysterious character who is a witness to the Parisian life. A common theme of Paris and love fuses all.

In a small Southern American town, Paul, who is known for having sexual relations with every girl in town, falls in love with his best friend's younger sister who is a virgin. Paul must try to prove to everyone that this time he is in love rather than in lust.

Craig is a high-school junior in the gifted program, infatuated with his best friend's girl. When he realizes he's suicidal, he checks himself into the psychiatric ward of a hospital, thinking they'll do an observation, help him, and send him home in time for school the next day. Once in, however, he must stay for a week; the juvenile ward is being renovated, so he's in with adults as well as a few youths. Bobby, a man with a young daughter, shows him around; Craig notices Noelle, about his age. He tries to keep his friends from finding out where he is. He draws, goes to therapy, sings, helps Bobby rehearse an interview. Is this the stuff of insight?

The love which binds mother and daughter - seen through the prism of one mother's life as it crests with optimism, navigates a turning point, and ebbs to its close. Overcome by the power of memory, Ann Lord (Vanessa Redgrave) reveals a long-held secret to her concerned daughters; Constance Haverford (Natasha Richardson), a content wife and mother, and Nina Mars (Toni Collette), a restless single woman. Both are bedside when Ann calls out for the man she loved more than any other. But who is this "Harris", wonder her daughters, and what is he to our mother? While Constance and Nina try to take stock of Ann's life and their own lives, their mother is tended to by a night nurse (Dame Eileen Atkins) as she journeys in her mind back to a summer weekend around fifty years before, when she was Ann Grant (Claire Danes), a young woman who has come from New York City to be maid of honor at the high-society Newport wedding of her dearest friend from college, Lila Wittenborn (Mamie Gummer). The bride-to-be is jittery, and turns to her maid of honor rather than her own mother for support. Ann stays close to her friend, yet is even closer to Lila's irrepressible brother Buddy Wittenborn (Hugh Dancy). Unexpected feelings surge forth once Ann meets wedding guest Harris Arden (Patrick Wilson), a life-long friend and intimate of the Wittenborn family. Ann's love for Harris will change her life, and those of her daughters, forever.

Kym Buchman has been in drug rehab for nine months, during which time she has been clean. She is released temporarily from the facility to attend her sister Rachel Buchman's wedding. During her release, Kym is staying at the family home, where the wedding is taking place. As such, it is like Grand Central Station for the duration of Kym's stay, which may not be the most conducive situation for her in constantly being exposed to the watching eyes of those who know and don't yet know her, but know of her situation. The reunion with her family members starts off well enough, but issues around Kym's release from rehab quickly surface. Kym and Rachel's father, Paul Buchman, wants to make sure that Kym is all right at all times, which to Kym feels instead like he doesn't trust her. Rachel slowly begins to resent Kym's situation taking over what is supposed to be the happiest day of her life, some of which is directed by Kym, some of which isn't. One person present but largely not included in the last minute wedding planning work is Kym and Rachel's mother, Abby, from who Paul is divorced. The two have since married other people. Outwardly, Abby has been nurturing of Kym throughout her life. However, what is one of the key moments in Kym's drug induced life, and in their collective family's lives, may profoundly affect the wedding. Beyond how Kym's presence affects the wedding, the goings-on of the family during Kym's short stay may either bring them closer together or tear them apart.

Teenagers Rose and Bennett were in love, and then a car crash claimed Bennett's life. He left behind a grieving mother, father, and younger brother, and Rose was left all alone. She has no family to turn to for support, so when she finds out she's pregnant, she winds up at the Brewers' door. She needs their help, and although they can't quite admit it, they each need her so they can begin to heal.

An emotionally fragile woman recently released from a mental hospital for self mutilation goes to school to gain secretarial skills to gain employment. She has an alcoholic father and a co-dependent mother who are clueless as to who she really is which a tormented soul who really wants to find something with which she can find success. She is a great secretary and finds a job with a unique, old fashioned, but off center in charge boss with a somewhat sadistic sexual proclivity. She grows and evolves and so does he.

In 2003, 38-year-old graphic artist Oliver Fields has just lost his father Hal to cancer, 5 years after his mother Georgia's death. Oliver is naturally sullen because of his relationships with his parents growing up (especially his mother, who had a unique view of life) and watching their cordial but somewhat distant marital relationship, but he's more so now as he deals with his personal losses. He embarks on a relationship with French actress Anna, hoping that his re-energized relationship with Hal following Georgia's death, and Hal's new outlook on life, will show him how to act in a loving relationship. After Georgia's death, Hal came out of the closet and began to live with a new joie de vivre and have an open relationship with Andy, a much-younger man. Oliver's relationship with Anna has other obstacles, including her own vagabond lifestyle and Oliver inheriting Arthur, Hal's very needy Jack Russell terrier.

It's 1955. Frank and April Wheeler, are in the 'seven year itch' of their marriage; they're not happy. April has forgone her dream of being an actress, and Frank hates his job. One day, April suggests they move to Paris as a means to rejuvenate their life.