Young Simone is involved in a near fatal car crash, and as she questions her mortality, she also decides to have a baby. Her candidate for a father is her best friend Phillipe who happens to be seeing someone. He agrees, as long as they conceive in Salt Lake City, in the desert. The trip teaches many lessons about love, solitude, and self-discovery.

George (Richard Burton) and Martha (Dame Elizabeth Taylor) are a middle-aged married couple, whose charged relationship is defined by vitriolic verbal battles, which underlies what seems like an emotional dependence upon each other. This verbal abuse is fueled by an excessive consumption of alcohol. George being an associate history professor in a New Carthage university where Martha's father is the President adds an extra dimension to their relationship. Late one Saturday evening after a faculty mixer, Martha invites Nick (George Segal) and Honey (Sandy Dennis), an ambitious young biology professor new to the university and his mousy wife, over for a nightcap. As the evening progresses, Nick and Honey, plied with more alcohol, get caught up in George and Martha's games of needing to hurt each other and everyone around them. The ultimate abuse comes in the form of talk of George and Martha's unseen sixteen-year-old son, whose birthday is the following day.

In Paris, the shy bureaucrat Trelkovsky rents an old apartment without bathroom where the previous tenant, the Egyptologist Simone Choule, committed suicide. The unfriendly concierge (Shelley Winters) and the tough landlord Mr. Zy establish stringent rules of behavior and Trelkovsky feels ridden by his neighbors. Meanwhile he visits Simone in the hospital and befriends her girlfriend Stella. After the death of Simone, Trelkovsky feels obsessed for her and believes his landlord and neighbors are plotting a scheme to force him to also commit suicide.

Watchlist