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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Eddie "Gonzo" Gilman is starting a revolution. When the wild-eyed rebel journalist is ousted from his prep school's newspaper by its über-popular editor, Eddie fronts an underground movement to give a voice to all the misfits, outcasts, and nerds. Soon the power of the press is in Eddie's hands... but will he use it wisely?

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Violet and her two cohorts attempt to help their "less-fortunate" students at Seven Oaks College - primarily by running a Suicide Prevention Centre and offering their off-beat advice whenever they get a chance. Violet's newest rescue is transfer student, Lily, and Violet wants to teach her how to talk and dress properly, and how to select appropriate men to be interested in. Along their way in helping everybody at the college, the damsels teach the fraternity doofi to hit the books, they get their hearts broken, but then attempt to start an international dance craze.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

L.A. soft-porn writer Carter Webb is frustrated enough, after his actress girlfriend dumps him, to need a serious break. He decides to spend it with his grandmother, who can't really take care of herself and her Detroit suburb house anyway. Helpful Carter soon overcomes mishaps to bond with the foxy neighbor across the street and her daughters. Helping them actually helps him regain perspective and self-confidence.

Precocious Oliver struggles with being popular in school but when a dark-haired beauty takes interest in him, he's determined to become the best boyfriend in the world. Meanwhile, his parents' already rocky relationship is threatened when his mother's ex-boyfriend moves in next door. Oliver makes some unorthodox plans to ensure that his parents stay together and that Jordana still likes him.

Celeste and Jesse have been best friends forever. They dated in high school, got married, and now they're getting divorced. Their best friends don't think they can maintain their friendship throughout the dissolution of their marriage, but Celeste and Jesse don't think there will be a problem. But that's before Jesse gets into a relationship that Celeste doesn't think he can handle, and Celeste finds it harder to move on than she originally thought.

After it looks as if she's left his life for good this time, Tom Hansen reflects back on the just over one year that he knew Summer Finn. For Tom, it was love at first sight when she walked into the greeting card company where he worked, she the new administrative assistant. Soon, Tom knew that Summer was the woman with whom he wanted to spend the rest of his life. Although Summer did not believe in relationships or boyfriends - in her assertion, real life will always ultimately get in the way - Tom and Summer became more than just friends. Through the trials and tribulations of Tom and Summer's so-called relationship, Tom could always count on the advice of his two best friends, McKenzie and Paul. However, it is Tom's adolescent sister, Rachel, who is his voice of reason. After all is said and done, Tom is the one who ultimately has to make the choice to listen or not.

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

Hollywood actor Johnny Marco, nested in his luxury hotel of choice, is a stimulated man. Drinking, parties and women keep a creeping boredom under wraps in between jobs. He is the occasional father of a bright girl, Cleo, who may be spoiled but doesn't act it. When Cleo's mother drops her off and leaves town, Johnny brings her along for the ride, but can he fit an 11-year-old girl into his privileged lifestyle?

Although cheerful, friendly, intelligent, well-dressed, authentic and wealthy, Charlie Bartlett has problems. With his father gone and his mother loopy and clueless, he's been expelled from every private school for his victimless crimes. Now he's in a public school getting punched out daily by the school thug. He ever longs to be popular - the go-to guy - and the true crux of his troubles is that he invariably finds the means to this end, whatever that might be. At Western Summit High, he makes peace with his tormentor by going into business with him - listening to kids' problems and selling them prescription drugs. Charlie's a hit, but attraction to Susan (daughter of the school's laissez-faire principal), new security cameras on campus, a student's overdose, and Charlie's open world view all converge to get him in serious trouble. Can this self-made physician possibly heal himself and just be a kid?

Do we ever get what we want? Brian sells mattresses in a warehouse store. His father and older brothers have material success; he wants a child. He's applied to adopt a baby from China. A man who appears homeless seems to be stalking Brian with violent intent. He meets Happy, the daughter of a rich, quirky customer. She doesn't stick to anything, but she and Brian hit it off, except for her vomiting when she learns about his adoption idea. He wants her to meet his family, and there's a call about the adoption. What will Happy do?

After a little white lie about losing her virginity gets out, a clean cut high school girl sees her life paralleling Hester Prynne's in "The Scarlet Letter," which she is currently studying in school - until she decides to use the rumor mill to advance her social and financial standing.

Nora Wilder is freaking out. Everyone around her is either in a relationship, married, or has children. Nora is in her thirties, alone with job she's outgrown and a mother who constantly reminds her of it all. Not to mention her best friend Audrey's "perfect marriage". But after a series of disastrous dates, Nora unexpectedly meets Julien, a quirky Frenchman who opens her eyes to a lot more than love.

Craig is a high-school junior in the gifted program, infatuated with his best friend's girl. When he realizes he's suicidal, he checks himself into the psychiatric ward of a hospital, thinking they'll do an observation, help him, and send him home in time for school the next day. Once in, however, he must stay for a week; the juvenile ward is being renovated, so he's in with adults as well as a few youths. Bobby, a man with a young daughter, shows him around; Craig notices Noelle, about his age. He tries to keep his friends from finding out where he is. He draws, goes to therapy, sings, helps Bobby rehearse an interview. Is this the stuff of insight?

At 16, Nick Twisp is wry about his teen funk: he lives in Oakland with his sex-addled mother; his father's child support is her meal ticket. While camping in Ukiah, Nick meets Sheeni: for him, it's love at first sight. Nick has to figure out how to get his father a job in Ukiah, then how to get sent to live with his father, then how to get close to Sheeni, whose religious parents may want her sent away from temptation to a boarding school. There's also Sheeni's all-American boyfriend to contend with. Overwhelmed by the challenges, Nick's about to give up when he conjures an alter ego who whispers revolt into his ear. Nick is not altogether hapless, but can this end well?

Believing the quote that you are born alone, die alone and everything else is an illusion, George doesn't see the point of life, school, or homework. Then he meets Sally and he now has a reason to go to school and make friends, even if he's not ready to admit to himself or to her that he likes her. The school's principal and art teacher introduce him to an alumni, and successful artist, Dustin, who can help guide George along life's path, but other distractions start surfacing, and George might not even be able to graduate from high school.