In NYC's Chinatown, recluse math genius Max (Sean Gullette) believes "everything can be understood in terms of numbers," and he looks for a pattern in the system as he suffers headaches, plays Go with former teacher Sol Robeson (Mark Margolis), and fools around with an advanced computer system he's built in his apartment. Both a Wall Street company and a Hasidic sect take an interest in his work, but he's distracted by blackout attacks, hallucinations, and paranoid delusions..

Eva's a mother trying to piece together her life following an incident caused by her odd child, Kevin. Once a successful writer, she's forced to take whatever comes her way, in spite of the increasingly bizarre and dangerous things Kevin says, or does.

Still untarnished by the false promises of the rapacious film industry, the wide-eyed actress, Betty, sets foot on bustling, sun-kissed Hollywood. Brimming with hope, and eager to spread her wings and prove her worth, Betty moves in Aunt Ruth's expensive apartment, unbeknownst to her, however, that fate has other plans in store for her, setting the stage for life-altering experiences with the unexpected, the indecipherable, and the unknown. Now, in the centre of an elaborate labyrinth of half-truths, faded memories, unrequited loves, and dangerous encounters with the city's ugly face lies a strange key to a mysterious keyhole, an even stranger indigo-blue cube, the young director, Adam, and one cryptic woman: the amnesiac brunette and devilishly seductive car-crash survivor, Rita. But, time flies and Rita's opaque past demands answers. After all, both women deserve the truth. What is the secret of the serpentine, dream-crushing Mulholland Drive?

Sam Bell has a three year contract to work for Lunar Industries. For the contract's entire duration, he is the sole employee based at their lunar station. His primary job responsibility is to harvest and periodically rocket back to Earth supplies of helium-3, the current clean and abundant fuel used on Earth. There is no direct communication link available between the lunar station and Earth, so his only direct real-time interaction is with GERTY, the intelligent computer whose function is to attend to his day to day needs. With such little human contact and all of it indirect, he feels that three years is far too long to be so isolated; he knows he is beginning to hallucinate as the end of his three years approaches. All he wants is to return to Earth to be with his wife Tess and their infant daughter Eve, who was born just prior to his leaving for this job. With two weeks to go, he gets into an accident at one of the mechanical harvesters and is rendered unconscious. Injured, he awakens back at the station in the infirmary, he assumes assisted by GERTY. GERTY tells him that a rescue team named Eliza will come to the station to clean up the aftermath of the accident. After his recuperation, he takes an unauthorized trip back to the broken harvester, where he makes an unexpected discovery. Because of his find, he begins to doubt his sanity, then his true identity, then the company and GERTY's willingness to do what is best for him. Because of his resulting beliefs, his sole mission becomes how to get back to Earth on his own.

In the not-so-far future the polar ice caps have melted and the resulting rise of the ocean waters has drowned all the coastal cities of the world. Withdrawn to the interior of the continents, the human race keeps advancing, reaching the point of creating realistic robots (called mechas) to serve them. One of the mecha-producing companies builds David, an artificial kid which is the first to have real feelings, especially a never-ending love for his "mother", Monica. Monica is the woman who adopted him as a substitute for her real son, who remains in cryo-stasis, stricken by an incurable disease. David is living happily with Monica and her husband, but when their real son returns home after a cure is discovered, his life changes dramatically.

Elliot Moore is a high school science teacher who quizzes his class one day about an article in the New York Times. It's about the sudden, mysterious disappearance of bees. Yet again Nature is doing something inexplicable, and whatever science has to say about it will be, in the end, only a theory. Scientists will bring out more theories, but no explanations, when a more urgent dilemma hits the planet. It begins in Central Park. Suddenly and inexplicably, the behavior of everyone in the park changes in a most bizarre and horrible way. Soon, the strange behavior spreads throughout the city and beyond. Elliot, his wife, Alma, and Jess, the young daughter of a friend, will only have theories to guide them where to run and where to hide. But theories may not be enough.

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