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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Enid and Rebecca after they finish the high school. Both have problems relating to people and they spend their time hanging around and bothering creeps. When they meet Seymour who is a social outsider who loves to collect old 78 records, Enid's life will change forever.

Seventh-grade is no fun. Especially for Dawn Weiner when everyone at school calls you 'Dog-Face' or 'Wiener-Dog.' Not to mention if your older brother is 'King of the Nerds' and your younger sister is a cutesy ballerina who gets you in trouble but is your parents' favorite. And that's just the beginning--her life seems to be falling apart when she faces rejection from the older guy in her brother's band that she has a crush on, her parents want to tear down her 'Special People's Club' clubhouse, and her sister is abducted....

Successful Carolinian George Johnsten meets Chicago art gallery owner Madeleine at an electoral benefit art auction- love at first sight. Madeleine decides to meet a Southern original artist, so George seizes the opportunity to come along and present her to his North Carolina parents Eugene and Peg, drop-out brother Johny and his high-pregnant wife Ashley. Confronting the outsider soon opens a can of worms as emotions revive or emerge, like admiration and jealousy.

The relationship between two brothers, a father trying to connect with his sons and the young woman who gets between the three of them. The story begins when Caleb Sinclaire reluctantly picks up his brother Peter at college and brings him and his new girlfriend Emma home for the Thanksgiving holiday. Caleb, who recently broke up with his long-time girlfriend and is wary of relationships, warns Peter that Emma will end up hurting him, but he can't stop himself from being drawn to her. As Caleb's infatuation with Emma grows, he must decide whether to act on his feelings or protect his brother's first love.

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

About a recent college grad who returns home while she tries to figure out what to do with her life.

Coming of age in Plainsboro, New Jersey. High school student Hal Hefner stutters. On the evening his parents stop arguing and separate, 43 miles away at the state tournament, his school's legendary debater, Ben Wekselbaum, goes blank mid-sentence, Ben's teammate Ginny Ryerson doesn't get a first-place trophy, and the world changes. That fall, to Hal's amazement, Ginny recruits him for the debate team, mentors him, and will be his partner. He still has his stutter, but he works hard and he falls in love with Ginny. On the day of the first debate of the season, the world changes again. From then until the day of the state tournament, Hal has a lot to sort out. Is love rocket science?

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who lives in the building and fakes her death to get the girl to let him in her apartment but holds a butcher knife between them. So it goes and he is no longer living in his car. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her to get out of the apartment, cooking, washing her hair. Both have demons and, as their stories become more clear, his addictive personality and her sex nausea may be on a collision course.

Tracy, a lonely college freshman in New York, is rescued from her solitude by her soon-to-be stepsister Brooke, an adventurous gal about town who entangles her in alluringly mad schemes. Mistress America is a comedy about dream-chasing, score-settling, makeshift families, and cat-stealing.

A naive college graduate, Amy, who believes she's destined to be a great poet, begrudgingly accepts a job in a shop while she pursues a mentorship with reclusive writer Rat Billings.

'Me and You and Everyone We Know' is a poetic and penetrating observation of how people struggle to connect with one another in an isolating contemporary world. Christine Jesperson is a lonely artist and "Eldercab" driver who uses her fantastical artistic visions to draw her aspirations and objects of desire closer to her. Richard Swersey, a newly-single shoe salesman and father of two boys, is prepared for amazing things to happen, but when he meets the captivating Christine, he panics. Life is not so oblique for Richard's six-year-old Robby, who is having a risqué Internet romance with a stranger, or Robby's 14-year-old brother Peter, who becomes the guinea pig for neighborhood girls practicing for their future of romance and marriage.

Andrew Largeman is a semi-successful television actor who plays an intellectually disabled quarterback. His somewhat controlling and psychiatrist father has led Andrew ("Large") to believe that his mother's wheelchair-bound life was his fault. Andrew decides to lay off the drugs that his father and his doctor made him believe that he needed, and began to see life for what it is. He began to feel the pain he had longed for, and began to have a genuine relationship with a girl who had some problems of her own.

T.J., a high school freshman, lost his mother two months before in a car accident: his father pops pills and sits on the couch; his grandmother holds things together, chatting and cooking. T.J. wants the car back from the salvage yard where the owner's son is a bully. By happenstance, Hesher, a foul-mouthed squatter, moves in with T.J's family. T.J. also meets Nicole, a grocery clerk near poverty who helps him once. Hesher involves T.J. in crime, the bully is omnipresent, mom's car is slipping away, dad has checked out, T.J. watches Nicole at work, and his grandma invites him to join her morning walk: the odds are long that T.J. can assemble a family to help him thrive.

Justin is a teenager boy, who has an oral obsession with his thumb. His mother seems to be a normal housekeeper, but she has her own obsessions as well, like a crush on a TV-star. The only person who's aware of Justin's problem is his father, manager in a store, but none of his advices seem to be working for Justin. The kid is signed up in a debate workshop, but the thing isn't going well, because he has his mind in a pretty classmate and, of course, in his thumb, affecting all the rest of his classes. So, Justin is a loner kid in the school, who prefers to lock himself in the bathroom and suck his thumb. Justin's dentist, a mystical-hippie person, will try to help to overcome his thumb problem, through the hypnosis. But the school's psychologist will diagnose Justin with the Attention Deficit Disorder, and will prescribe him some drugs. Suddenly, Justin's problem with his thumb will disappear, becoming an hyperactive genius, winning several debate contests and the admiration from his teacher. Nevertheless, more serious problems will come for Justin with his mother, his father and with a drug addiction.

In Albuquerque, Sheryl Hoover brings her suicidal brother Frank to the breast of her dysfunctional and emotionally bankrupted family. Frank is homosexual, an expert in Proust. He tried to commit suicide when he was rejected by his boyfriend and his great competitor became renowned and recognized as number one in the field of Proust. Sheryl's husband Richard is unsuccessfully trying to sell his self-help and self-improvement technique using nine steps to reach success, but he is actually a complete loser. Her son Dwayne has taken a vow of silence as a follower of Nietzsche and aims to be a jet pilot. Dwayne's grandfather Edwin was sent away from the institution for elders (Sunset Manor) and is addicted in heroin. When her seven-year-old daughter Olive has a chance to dispute the Little Miss Sunshine pageant in Redondo Beach, California, the whole family travels together in their old Volkswagen Type 2 (Kombi) in a funny journey of hope of winning the talent contest and to make a dream come true.

Frances lives in New York, but she doesn't really have an apartment. Frances is an apprentice for a dance company, but she's not really a dancer. Frances has a best friend named Sophie, but they aren't really speaking anymore. Frances throws herself headlong into her dreams, even as their possible reality dwindles. Frances wants so much more than she has but lives her life with unaccountable joy and lightness.