Harry and Sally meet when she gives him a ride to New York after they both graduate from the University of Chicago. The film jumps through their lives as they both search for love, but fail, bumping into each other time and time again. Finally a close friendship blooms between them, and they both like having a friend of the opposite sex. But then they are confronted with the problem: "Can a man and a woman be friends, without sex getting in the way?"

At 16, Nick Twisp is wry about his teen funk: he lives in Oakland with his sex-addled mother; his father's child support is her meal ticket. While camping in Ukiah, Nick meets Sheeni: for him, it's love at first sight. Nick has to figure out how to get his father a job in Ukiah, then how to get sent to live with his father, then how to get close to Sheeni, whose religious parents may want her sent away from temptation to a boarding school. There's also Sheeni's all-American boyfriend to contend with. Overwhelmed by the challenges, Nick's about to give up when he conjures an alter ego who whispers revolt into his ear. Nick is not altogether hapless, but can this end well?

Henry Roth lives in a Hawaiian paradise with the company of endless women with no strings attached. This is until he meets Lucy Whitmore. Both Henry and Lucy enjoy the company of each other and feel the start of a serious relationship occurring. Approaching Lucy the next day, Henry is confused when Lucy fails to recognize him. This is the moment Henry discovers that Lucy actually suffers from short term memory loss and can't remember each individual day. Henry won't let this stop him and is prepared to make her fall in love with him all over again, each and every day.

Barbra and Johnny visit their father's grave in a remote cemetery when they are suddenly set upon by zombies. Barbra manages to get away and takes refuge in what seems to be an abandoned farm house. She is soon joined by Ben who stopped at the house in need of gas. Beset by the walking dead all around them Ben does his best to secure the doors and windows. The news reports are grim however with creatures returning to life everywhere. Barbra and Ben are surprised when they realize there are 5 people hiding out in the basement: Harry, Helen and Karen Cooper; and a young couple, Tom and Judy. Dissensions sets in almost immediately with Harry Cooper wanting to be in charge. As their situation deteriorates, their chances of surviving the night lessen minute by minute.

On the eve of Halloween, on October 1977, four friends--Bill, Jerry, Mary, and Denise--embark on an exciting cross-country road trip to write a guidebook about offbeat roadside attractions in America's less-travelled roads. Before long, the young explorers chance upon Captain Spaulding's Museum of Monsters and Madmen, only to become infatuated with the local legend of a deranged serial-killer doctor, and cross paths with the mysterious hitchhiker, Baby. However, when the unsuspecting group meets Baby's eccentric family after having a flat tyre, an endless night of terror, torture, and murder ensues. Has anyone ever got out alive from the House of Thousand Corpses?

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