This is a story about sports-broadcaster-turned-morning-talk-show-host Danny Tanner and his three little girls, D.J. (Donna Jo), Stephanie, and Michelle Tanner. Before the show begins, Danny Tanner's wife is killed by a drunk driver, so he needs help raising his daughters. He asks his rock-musician brother-in-law Jesse Katsopolis and his comedian best friend Joey Gladstone to move in with them. As the show goes on, Jesse marries Rebecca Donaldson, Danny's talk-show co-host, and they have twin sons, Nicholas Katsopolis.

After his friends all go their separate ways, Joey Tribianni leaves New York for Hollywood to pursue his acting career full time. His sister Gina buys him a nice apartment, and he finds a new roommate in his 20-year old nephew Michael (Gina had him when she was 16), who is literally a rocket scientist. Michael's book smarts and Joey's people smarts allow them to help each other out whenever they can, and make them nice companions.

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