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Four childhood friends, now in their thirties, are having a reunion. Their lives have gone separate and very different ways. Together again they reminisce about their younger years, especially the eventful period when they were 12 years old.

Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Jenna is unhappily married, squirreling away money, and hoping to win a pie-baking contest so, with the prize money, she'll have enough cash to leave her husband Earl. She finds herself pregnant, which throws her plans awry. She bakes phenomenal pies at Joe's diner, listens to old Joe's wisdom, tolerates her sour boss Cal, is friends with Dawn and Becky (her fellow waitresses), and finds a mutual attraction with the new doctor in town. As the pregnancy advances, life with Earl seems less tolerable, a way out less clear, and the affair with the doctor complicated by his marriage. What options does a waitress have?

Chicago Sun Times copy editor Josie Gellar (25), who was desperate to graduate from perfectionist copy editor to reporter, gets her chance when the goody owner orders the editor to cover the high-school scene by undercover. Josie, who was a frustrated, ridiculed nerd, gets a popular make-over from her drop-out, naturally funny brother Rob Geller. Both siblings find love and joys of youth again. But in Josie's case, it's sensitive bachelor teacher Sam Coulson, who enjoys sophisticated conversation. As the publication deadline approaches, the price of blowing their cover seems ever more daunting, yet inevitable unless she sacrifices her career.

Jake and Brian are friends. They are Jewish and Catholic respectively. They would grow up and become a rabbi and priest. Anna, whom they knew when they were younger, comes back to town a stunning woman. Jake is up to be the head of his synagogue but he is not married which doesn't make his appointment any easier. Jake finds himself attracted to Anna but because she's not Jewish, he can't marry her as it would make his appointment less likely. Brian also finds himself attracted to Anna, but the priesthood doesn't allow that. Their friendship is strained when each learns of the other's feelings for her.

Twenty-something native Vermonter Mirabelle Buttersfield, having recently graduated from college, is finding her new life in Los Angeles not quite what she was expecting or hoping. An aspiring artist, she is barely eking out a living working as a clerk at the women's evening gloves counter at Saks Fifth Avenue in Beverly Hills and thus she can barely make the payments on her massive student loans. She treats her job with a certain distance, often daydreaming as she watches the life of the rich as they shop at the store. She has made no friends, including from among her Saks colleagues, and thus lives a solitary existence, which does not assist in her dealing with her chronic clinical depression. So it is with some surprise that two men with a romantic interest in her enter her life almost simultaneously. The first is poor slacker Jeremy, who works as an amplifier salesman/font designer. Mirabelle continues dating Jeremy as only a relief to her solitary life, as Jeremy doesn't seem to understand how to treat her in the way she wants. Shortly after meeting Jeremy, she meets the second, wealthy fifty-something Ray Porter, who is the antithesis of Jeremy in almost every respect, including the fact that Ray is unwilling or unable to commit to Mirabelle, about which he is up front to her. To Mirabelle, that lack of commitment from Ray seems to be in name only, and as such she increasingly sees Ray as her boyfriend. Mirabelle has to decide if a long term future is either in the cards with Jeremy or Ray, which is made all the more complicated by an action by Jeremy to an off the cuff comment that she makes to him.

Sisters Kat and Daisy work along with Jojo at the pizza parlour in Mystic, Connecticut. Kat, shortly off to Yale, finds herself drawn to a local architect she is babysitting for, while her more tearaway sister starts dating a guy from the money side of the tracks. Jojo leaves her man at the altar; she loves him but shies away from commitment. Meanwhile the fame of the pizza continues to spread; it seems to contain something almost ..... mystic.

Jonathan, a naive country boy, gets a scholarship to a classy prep school, where he rooms with suave, rich and handsome Skip. Skip decides it is his duty to see that Jonathan loses his virginity, so he sends Jonathan to Chicago, where Jonathan meets Ellen, a beautiful older woman, and they be- gin an affair which ends abruptly when Ellen discovers Jonathan is 17. During Christmas break, Jonathan visits Skip's house and discovers that Ellen is Skip's mother. Ellen tells Jonathan to leave when he rejects her advances, but then begins calling him and begging to see him. Finally, Jonathan agrees to meet her and plans to end the affair, but Ellen seduces him--and that's when Skip, who followed Jonathan, discovers them.

About a recent college grad who returns home while she tries to figure out what to do with her life.

Ronald Miller is tired of being a nerd, and makes a deal with one of the most popular girls in school to help him break into the "cool" clique. He offers her a thousand dollars to pretend to be his girlfriend for a month. It succeeds, but he soon learns that the price of popularity may be higher than he expected.

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who lives in the building and fakes her death to get the girl to let him in her apartment but holds a butcher knife between them. So it goes and he is no longer living in his car. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her to get out of the apartment, cooking, washing her hair. Both have demons and, as their stories become more clear, his addictive personality and her sex nausea may be on a collision course.

Although cheerful, friendly, intelligent, well-dressed, authentic and wealthy, Charlie Bartlett has problems. With his father gone and his mother loopy and clueless, he's been expelled from every private school for his victimless crimes. Now he's in a public school getting punched out daily by the school thug. He ever longs to be popular - the go-to guy - and the true crux of his troubles is that he invariably finds the means to this end, whatever that might be. At Western Summit High, he makes peace with his tormentor by going into business with him - listening to kids' problems and selling them prescription drugs. Charlie's a hit, but attraction to Susan (daughter of the school's laissez-faire principal), new security cameras on campus, a student's overdose, and Charlie's open world view all converge to get him in serious trouble. Can this self-made physician possibly heal himself and just be a kid?

When Carla Tate, now a young woman, is 'graduated' out of the training school where she has resided for many years because she is mentally challenged, her hope is that she will be accepted for all that she can now do for herself. But Carla's family is wealthy which permits her mother, already blinded to her daughter's rather high-functioning abilities, to try and provide for Carla beyond her needs or desires, bringing forth the inevitable confrontations... for what Carla may lack in mental ability she certainly makes up for in her insistence on being independent, even to living in her own apartment. But if this isn't enough, into the mix comes a young man, equally challenged mentally, who moves Carla beyond anyone's control...

Jerome, a kid from the suburbs who loves to draw, goes to New York City's Strathmore College for his freshman year as a drawing major. Competition and petty jealousy consume faculty and students, with an end-of-first-semester best-student award held out as a grand plum. Worse, a strangler is on the loose, killing people on or next to campus. The idealistic Jerome falls in love with Audrey, a student who models for life-drawing classes and who responds to his sweetness. But he has a rival: the clean-cut, manly Jonah, also a first-year drawing student, whose primitive work draws raves and Audrey's attention. As cynicism seems to corrode everything, Jerome is desperate to win.

New Year's Eve, 1981, the Lower East Side. Monica's having a party, but as late as 9, no one's there. She stews (and drinks). Folks are on their way, all looking for love, sex, or both. En route, paths cross, gambits misfire: a performance artist, her boyfriend until today and his long-time pal Lucy, two Long Island high-school girls, two punk rockers, a bartender, a Scottish painter who's lousy in bed, a pretty face named Jack who runs when women say they love him, his cute but clumsy date Cindy, two trendy vamps, a loquacious cabby, the man-crazed Hillary, and Elvis Costello. Nearly everybody smokes, and nearly everybody scores. And all get who and what they deserve.

An emotionally fragile woman recently released from a mental hospital for self mutilation goes to school to gain secretarial skills to gain employment. She has an alcoholic father and a co-dependent mother who are clueless as to who she really is which a tormented soul who really wants to find something with which she can find success. She is a great secretary and finds a job with a unique, old fashioned, but off center in charge boss with a somewhat sadistic sexual proclivity. She grows and evolves and so does he.

Camden College. Sean Bateman is the younger brother of depraved Wall Street broker Patrick Bateman. He's also a drug dealer who owes a lot of money to "fellow" dealer Rupert Guest, as well as a well-known womanizer, for he sleeps with nearly half of the female population on campus. Lauren Hynde is, technically, a virgin. She's saving herself for her shallow boyfriend, Victor Johnson, who's left the States to backpack across Europe. Her slutty roommate, Lara, has the hots for Victor as well. Paul Denton, who used to date Lauren, is openly bisexual and attracted to Mitchell Allen, who's dating Candice to prove to Paul that he's not gay. Sean loves Lauren. Paul loves Sean. And Lauren may love Sean.

After yet another failed relationship, Mrs. Flax (Cher) ups her family to the east coast to start all over again. Reluctantly dragged along with her is her daughter Charlotte - going through a very confusing time of her life - who wants to become a nun, and instead falls in love with a quiet, mild-mannered church employee, to the mixed response of her mother. Set at around the time of the Kennedy Assassination.