After his friends all go their separate ways, Joey Tribianni leaves New York for Hollywood to pursue his acting career full time. His sister Gina buys him a nice apartment, and he finds a new roommate in his 20-year old nephew Michael (Gina had him when she was 16), who is literally a rocket scientist. Michael's book smarts and Joey's people smarts allow them to help each other out whenever they can, and make them nice companions.

Two couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.

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