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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Julie and Jason have been best friends for years with no romantic interest in each other. He sleeps with someone new every few days, and she's looking for Mr. Right. Now in their thirties, they notice that their friends seem to lose all their good qualities when they have children - child rearing and the spark of Eros don't seem to co-exist. So, they decide to have a child together, share in child rearing, but pursue their own romantic lives. Things go well until he meets Mary Jane and she meets Kurt. Both seem like perfect mates. What could go wrong?

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Violet and her two cohorts attempt to help their "less-fortunate" students at Seven Oaks College - primarily by running a Suicide Prevention Centre and offering their off-beat advice whenever they get a chance. Violet's newest rescue is transfer student, Lily, and Violet wants to teach her how to talk and dress properly, and how to select appropriate men to be interested in. Along their way in helping everybody at the college, the damsels teach the fraternity doofi to hit the books, they get their hearts broken, but then attempt to start an international dance craze.

Luke and Kate are co-workers at a Chicago brewery, where they spend their days drinking and flirting. They're perfect for each other, except that they're both in relationships. Luke is in the midst of marriage talks with his girlfriend of six years, Kate is playing it cool with her music producer boyfriend Chris. But you know what makes the line between "friends" and "more than friends" really blurry? Beer.

Stuck with writer's block, Sam (Justin Long) concocts a fake identity to snag local street artist Birdie (Evan Rachel Wood). After his roommate suggests checking her Facebook profile, Sam begins to shape himself into the ideal man for her. After pretending to accidentally meet at a comedy club and they become ballroom dance partners. Sam begins to write a novel based on their relationship. Can he keep up the charade as it gets more and more difficult?

After an extremely regrettable one night stand, two strangers wake up to find themselves snowed in after sleeping through a blizzard that put all of Manhattan on ice. They're now trapped together in a tiny apartment, forced to get to know each other way more than any one night stand should.

Celeste and Jesse have been best friends forever. They dated in high school, got married, and now they're getting divorced. Their best friends don't think they can maintain their friendship throughout the dissolution of their marriage, but Celeste and Jesse don't think there will be a problem. But that's before Jesse gets into a relationship that Celeste doesn't think he can handle, and Celeste finds it harder to move on than she originally thought.

Sasha and Paige's co-dependent friendship is tested as Paige gets serious with a guy for the first time.

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

About a recent college grad who returns home while she tries to figure out what to do with her life.

A teen artist living in 1970s San Francisco enters into an affair with her mother's boyfriend.

For aspiring comedian Donna Stern, everyday life as a female twenty-something provides ample material for her relatable brand of humor. On stage, Donna is unapologetically herself, joking about topics as intimate as her sex life and as crude as her day-old underwear. But when Donna winds up unexpectedly pregnant after a one-night stand, she is forced to face the uncomfortable realities of independent womanhood for the first time. Donna's drunken hookup - and epic lapse in prophylactic judgment - turns out to be the beginning of an unplanned journey of self-discovery and empowerment.

Adam (Mark Ruffalo) has just reached the 5-year mark in his sex addiction sobriety with help from his sponsor Mike (Tim Robbins). New-comer Neil (Josh Gad) seeks out Adam's help hoping that he'll be his mentor, but Neil doesn't have the same maturity and continues to harass women at work, on the street, and on the subway. Adam has also just met Phoebe (Gwyneth Paltrow), who might be perfect for him, but Adam hasn't been in a relationship since he recognized his addiction to sex, and Phoebe doesn't date addicts. As Adam navigates the romantic relationship waters, Mike struggles connecting to his former drug-addicted son who has just returned home, and Neil develops a relationship with another woman in his sex addicts group, but a platonic friendship might be exactly what he needs.

Rachel is a quick-witted and lovable stay-at-home mom. Frustrated with the realities of preschool auctions, a lackluster sex life and career that's gone kaput, Rachel visits a strip club to spice up her marriage and meets McKenna, a stripper she adopts as her live-in nanny.

We like Florence: she's considerate, sweet, pretty, and terrific with kids and dogs. She's twenty-five, personal assistant to an L.A. family that's off on vacation. Her boss's brother comes in from New York City, fresh from a stay at an asylum, to take care of the house. He's Roger, a forty-year-old carpenter, gone from L.A. for fifteen years. He arrives, doesn't drive, and needs Florence's help, especially with the family's dog. He's also connecting with former band-mates - two men and one woman with whom he has a history. He over-analyzes, has a short fuse, and doesn't laugh at himself easily. As he navigates past and present, he's his own saboteur. And what of Florence? is Roger one more responsibility for her or something else?

In New York City, Thom is broke and jobless, illegally working as a taxi driver just to make some quick cash to try and pay his rent. Claire is a successful business-woman, but personally she's in shambles trying to recover from a bump in her marriage and then comes the phone call that her distant father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive. And so he does. The duo find themselves in Pennsylvania and make the rash decision to drive across the country. On the road to California, there are many detours, as the obstacles and secrets force them to learn about themselves and each other.

Can two serial cheaters get a second chance at love? After a one-night stand in college, New Yorkers Lainey (Alison Brie) and Jake (Jason Sudeikis) meet by chance twelve years later and discover they each have the same problem: because of their monogamy-challenged ways, neither can maintain a relationship. Determined to stay friends despite their mutual attraction, they make a pact to keep it platonic, a deal that proves easier said than done.