The Doctor, a Time Lord from the race whose home planet is Gallifrey, travels through time and space in their ship the TARDIS (an acronym for Time and Relative Dimension In Space) with numerous companions. From time to time, the Doctor regenerates into a new form.

F.B.I. trainee Clarice Starling (Jodie Foster) works hard to advance her career, while trying to hide or put behind her West Virginia roots, of which if some knew, would automatically classify her as being backward or white trash. After graduation, she aspires to work in the agency's Behavioral Science Unit under the leadership of Jack Crawford (Scott Glenn). While she is still a trainee, Crawford asks her to question Dr. Hannibal Lecter (Sir Anthony Hopkins), a psychiatrist imprisoned, thus far, for eight years in maximum security isolation for being a serial killer who cannibalized his victims. Clarice is able to figure out the assignment is to pick Lecter's brains to help them solve another serial murder case, that of someone coined by the media as "Buffalo Bill" (Ted Levine), who has so far killed five victims, all located in the eastern U.S., all young women, who are slightly overweight (especially around the hips), all who were drowned in natural bodies of water, and all who were stripped of large swaths of skin. She also figures that Crawford chose her, as a woman, to be able to trigger some emotional response from Lecter. After speaking to Lecter for the first time, she realizes that everything with him will be a psychological game, with her often having to read between the very cryptic lines he provides. She has to decide how much she will play along, as his request in return for talking to him is to expose herself emotionally to him. The case takes a more dire turn when a sixth victim is discovered, this one from who they are able to retrieve a key piece of evidence, if Lecter is being forthright as to its meaning. A potential seventh victim is high profile Catherine Martin (Brooke Smith), the daughter of Senator Ruth Martin (Diane Baker), which places greater scrutiny on the case as they search for a hopefully still alive Catherine. Who may factor into what happens is Dr. Frederick Chilton (Anthony Heald), the warden at the prison, an opportunist who sees the higher profile with Catherine, meaning a higher profile for himself if he can insert himself successfully into the proceedings.

In 2029 the mutant population has shrunken significantly due to genetically modified plants designed to reduce mutant powers and the X-Men have disbanded. Logan, whose power to self-heal is dwindling, has surrendered himself to alcohol and now earns a living as a chauffeur. He takes care of the ailing old Professor X whom he keeps hidden away. One day, a female stranger asks Logan to drive a girl named Laura to the Canadian border. At first he refuses, but the Professor has been waiting for a long time for her to appear. Laura possesses an extraordinary fighting prowess and is in many ways like Wolverine. She is pursued by sinister figures working for a powerful corporation; this is because they made her, with Logan's DNA. A decrepit Logan is forced to ask himself if he can or even wants to put his remaining powers to good use. It would appear that in the near-future, the times in which they were able put the world to rights with razor sharp claws and telepathic powers are now over.

11-year-old Jake Chambers experiences visions involving a Man in Black who seeks to destroy a Tower and bring ruin to the Universe while a Gunslinger opposes him. However, Jake's mother, stepfather and psychiatrists dismiss these as dreams resulting from the trauma of his father's death the previous year. At his apartment home in New York City, a group of workers from an alleged psychiatric facility offer to rehabilitate Jake; recognizing them from his visions as monsters wearing human skin, he flees from the workers who give chase. Jake tracks down an abandoned house from one of his visions where he discovers a high-tech portal that leads to a post-apocalyptic world called Mid-World..

Thirty years after the events of Blade Runner (1982), a new Blade Runner, L.A.P.D. Officer "K" (Ryan Gosling), unearths a long-buried secret that has the potential to plunge what's left of society into chaos. K's discovery leads him on a quest to find Rick Deckard (Harrison Ford), a former L.A.P.D. Blade Runner, who has been missing for thirty years.

A rare atmospheric phenomenon allows a New York City firefighter to communicate with his son 30 years in the future via HAM radio. The son uses this opportunity to warn the father of his impending death in a warehouse fire, and manages to save his life. However, what he does not realize is that changing history has triggered a new set of tragic events, including the murder of his mother. The two men must now work together, 30 years apart, to find the murderer before he strikes so that they can change history--again.

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