Daten City is plagued by numerous Ghosts that feed upon its residents, but coming to the rescue are the angel sisters Panty and Stocking! Aided by the priest Garterbelt and their pet Chuck Zipper, these sisters from Heaven are assigned the duty of exorcising these specters. However, all they really want to do is have fun and slack off: Panty's goal is to bed one thousand men, and Stocking is only interested in sweets and desserts. To make matters worse, they were not sent from Heaven but rather thrown out, and the only way they can get back into Heaven is to defeat and destroy these Ghosts. And so this dirty pair is off to bust ghosts, and have a lot of fun on the side.