Jess, a bubbly, off-beat teacher, who is known to burst into song, catches her boyfriend with another woman. Newly homeless, she moves into a loft with three single guys she's never met before. Nick, a jaded, law-school dropout isn't the best of company. Schmidt is a flashy, eccentric businessman who believes he is Yahweh's gift to women. Winston is a former athlete who doesn't know what to do, but really needs a win. Can this dysfunctional group handle the adorkable new girl?

A teenage genius deals with the usual problems of growing up: hanging out with his best friend, going to parties, finding his style, and finding and having a girlfriend--all on top of being a licensed physician in a difficult residency program.

Tia and Tamera Mowry play twins who were separated at birth and by chance meet each other in a shopping mall. Ray Campbell, Tamera's adopted father, is very different from Tia's adopted mother, Lisa Landry, but the twins don't want to be separated so Ray and Lisa end up living together. The series often focuses on the trouble the twins get into due to their identical appearance and the love-hate relationship between Lisa and Ray.

As events unfold in her life, Clarissa explains to the viewer the motivations behind people's actions.

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