Enola Holmes takes on her first case as a detective, but to unravel the mystery of a missing girl, she'll need help from friends and brother Sherlock.

Set against the backdrop of 1950s New York, "Motherless Brooklyn" follows Lionel Essrog (Norton), a lonely private detective afflicted with Tourette's Syndrome, as he ventures to solve his friend's murder. Armed only with a few clues and the powerful engine of his obsessive mind, Lionel unravels closely-guarded secrets that hold the fate of the whole city in the balance.

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