Set in rural southern Ohio and West Virginia, The Devil All the Time follows a cast of compelling and bizarre characters from the end of World War II to the 1960s. There's Willard Russell, tormented veteran of the carnage in the South Pacific, who can't save his beautiful wife, Charlotte, from an agonizing death by cancer no matter how much sacrificial blood he pours on his "prayer log." There's Carl and Sandy Henderson, a husband-and-wife team of serial killers, who troll America's highways searching for suitable models to photograph and exterminate. There's the spider-handling preacher Roy and his crippled virtuoso-guitar-playing sidekick, Theodore, running from the law. And caught in the middle of all this is Arvin Eugene Russell, Willard and Charlotte's orphaned son, who grows up to be a good but also violent man in his own right.

Living in denial, the depressed, pill-popping child psychologist, Anna Fox, has holed herself up in her eerily vacant, ill-lit Manhattan brownstone apartment for the past ten long months, separated from her husband and their eight-year-old daughter. While unsuccessfully grappling with agoraphobia and intense panic attacks, suddenly, the Russells move in across the street, and brimming with curiosity, Anna decides to distract attention away from her problems by peeking into the lives of the unsuspecting new tenants. Then, one night, tensions flare, a deadly kitchen knife gleams in the dim light, and before long, someone ends up dead. Has troubled Anna, indeed, witnessed a gruesome scene of blood-stained domestic violence or is her wine-addled mind playing cruel tricks on her?

The patriarch of a wealthy and powerful family suddenly passes away, leaving his daughter with a shocking secret inheritance that threatens to unravel and destroy the family.

After a whirlwind romance in Monte Carlo with handsome widower Maxim de Winter (Armie Hammer), a newly married young woman (Lily James) arrives at Manderley, her new husband's imposing family estate on a windswept English coast. Naive and inexperienced, she begins to settle into the trappings of her new life, but finds herself battling the shadow of Maxim's first wife, the elegant and urbane Rebecca, whose haunting legacy is kept alive by Manderley's sinister housekeeper Mrs. Danvers (Kristin Scott Thomas).

In 1989 Tokyo, Lucy Fly, an enigmatic expat haunted by a painful past, enters into an intense relationship with Teiji, a handsome yet similarly troubled local photographer. Lucy's imperturbable exterior begins to crack when a naive newcomer, Lily Bridges, becomes entangled in their lives and ends up missing - suspected dead.

Iris, the statuesque dark-haired wife of the wealthy Parisian banker, Antoine Doriot, vanishes into thin air while the latter settles the bill at an elegant restaurant downtown. Furthermore, things will take a turn for the worse, when only a few hours later, much to his surprise, Antoine will receive a disturbing call from a merciless kidnapper demanding half a million euros in ransom in exchange for his abducted wife. As a result, under police surveillance, Antoine will follow to the letter the kidnapper's instructions with the intention to deliver the money, nevertheless, nothing will go as planned. By now, not much is making sense, while the helpless Iris is still missing. What has really happened to her?

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