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Harry and Sally meet when she gives him a ride to New York after they both graduate from the University of Chicago. The film jumps through their lives as they both search for love, but fail, bumping into each other time and time again. Finally a close friendship blooms between them, and they both like having a friend of the opposite sex. But then they are confronted with the problem: "Can a man and a woman be friends, without sex getting in the way?"

Melanie Parker, an architect and mother of Sammy, and Jack Taylor, a newspaper columnist and father of Maggie, are both divorced. They meet one morning when overwhelmed Jack is left unexpectedly with Maggie and forgets that Melanie was to take her to school. As a result, both children miss their school field trip and are stuck with the parents. The two adults project their negative stereotypes of ex-spouses on each other, but end up needing to rely on each other to watch the children as each must save his job. Humor is added by Sammy's propensity for lodging objects in his nose and Maggie's tendency to wander.

In London, Iris Simpkins writes a wedding column in a newspaper and nurtures an unrequited love for her colleague Jasper Bloom. Near Christmas, she is informed that Jasper is engaged to marry another colleague, and her life turns upside down. In Los Angeles, the movie-trailers maker Amanda Woods has just split with her unfaithful boyfriend Ethan and wants to forget him. Through a house exchange website, Amanda impulsively swaps her mansion for Iris' cottage in Surrey for the holidays. While in Surrey, Amanda meets Iris' brother and book editor Graham and they fall in love with each other. Meanwhile, Iris meets her new next door neighbor the ninety year old screenplay writer Arthur, who helps her retrieve her self-esteem, and the film composer Miles, with whom she falls in love.

Harry Sanborn is an aged music industry exec with a fondness for younger women like Marin, his latest trophy girlfriend. Things get a little awkward when Harry suffers a heart attack at the home of Marin's mother Erica. Left in the care of Erica and his doctor, a love triangle starts to take shape.

In North Carolina especially in Beaufort a prank on a guy goes wrong and puts the student in the clinic. Carter, a famous student with no plans for the future, is held responsible and forced to join in after-school community service activities as consequence, which include starring as the lead in the play. And participating in these activities is Jamie Sullivan, the reverend's daughter who has great ambitions and nothing in common with Landon. When Landon decides he wants to take his activities seriously, he asks Jamie for help and begins to spend most of his time with her. But he starts to like her, that he did not expect to do. They relationship, much to the chagrin of Landon's old popular friends and Jamie's strict reverend father. But when a heart-breaking secret becomes known that puts their relationship to the test, it is then that Landon and Jamie realize the true meaning of love and fate.

A woman who, by a promise made years earlier, is supposed to marry her best friend in three weeks, even though she doesn't want to. When she finds out that he's marrying someone else, she becomes jealous and tries to break off the wedding.

Frances Mayes is a San Francisco-based literature professor, literary reviewer and author, who is struggling in writing her latest book. Her outwardly perfect and stable life takes an unexpected turn when her husband files for divorce. He wants to marry the woman with whom he is having an affair. Frances supported her husband financially as he was writing his own book, and he sues her for alimony despite her financial difficulties. And he wants to keep the house. Frances eventually accepts her best friend Patti's offer of a vacation, a gay tour of Tuscany which Patti and her lesbian partner Grace originally purchased for themselves before Patti found out that she is pregnant. The gift is a means to escape dealing with the divorce, from which Patti feels Frances may never recover emotionally without some intervention. Feeling that Patti's assessment may be correct in that she has too much emotional baggage ever to return to San Francisco, Frances, while in Tuscany, impulsively ditches the tour to purchase an aged villa, which ends up being a fixer-upper. Frances has many obstacles in eking out a productive and happy life in her new surroundings, that happy life which she hopes will eventually include rediscovering romantic love. In a discussion with sympathetic real estate agent Signor Martini, Frances outlines what emotionally she wants to accomplish with the villa, despite none of those items in a substantive material sense currently being in her life. In response, Martini tells her the story of a set of railroad tracks that were laid between Vienna and Venice before an engine that could make the trek being built, a train which now regularly travels the route. The question becomes whether Frances, in going through the process, will be laying another Vienna to Venice track, and if so whether that end product emotionally will be exactly as she envisions.

Burke is a motivational speaker whose book about dealing with grief is a best seller. His wife died in a car accident three years ago. He's in Seattle to lead a week-long workshop on healing and to negotiate a major multi-media deal. But something's amiss: he's a closet drinker, he won't ride elevators, his moods swing, he's estranged from his wife's father, and he's very much alone. In a hotel hallway, he bumps into a woman arranging flowers, tries to chat with her, and gets the brush-off. She's Eloise, a local florist who's just broken up with a boyfriend. He's persistent and they eventually go to dinner - it goes badly. What's blocking Burke? Can the physician heal himself.

When brought together at a family event, two exes find themselves oddly attracted to each other after ten years of divorce. Although the couple think that this affair will stay in a different state, it brings itself back to their own city and disrupts their personal lives. While the couple still maintain other romances, they cannot help but to continue with their affair.

Holly Kennedy is beautiful, smart and married to the love of her life - a passionate, funny, and impetuous Irishman named Gerry. So when Gerry's life is taken by an illness, it takes the life out of Holly. The only one who can help her is the person who is no longer there. Nobody knows Holly better than Gerry. So it's a good thing he planned ahead. Before he died, Gerry wrote Holly a series of letters that will guide her, not only through her grief, but in rediscovering herself. The first message arrives on Holly's 30th birthday in the form of a cake, and to her utter shock, a tape recording from Gerry, who proceeds to tell her to get out and "celebrate herself". In the weeks and months that follow, more letters from Gerry are delivered in surprising ways, each sending her on a new adventure and each signing off in the same way; P.S. I Love You. Holly's mother and best friends begin to worry that Gerry's letters are keeping Holly tied to the past, but in fact, each letter is pushing her further into a new future. With Gerry's words as her guide, Holly embarks on a journey of rediscovery in a story about marriage, friendship and how a love so strong can turn the finality of death into a new beginning for life.

In a nursing home, resident Duke reads a romance story to an old woman who has senile dementia with memory loss. In the late 1930s, wealthy seventeen year-old Allie Hamilton is spending summer vacation in Seabrook. Local worker Noah Calhoun meets Allie at a carnival and they soon fall in love with each other. One day, Noah brings Allie to an ancient house that he dreams of buying and restoring and they attempt to make love but get interrupted by their friend. Allie's parents do not approve of their romance since Noah belongs to another social class, and they move to New York with her. Noah writes 365 letters (A Year) to Allie, but her mother Anne Hamilton does not deliver them to her daughter. Three years later, the United States joins the World War II and Noah and his best friend Fin enlist in the army, and Allie works as an army nurse. She meets injured soldier Lon Hammond in the hospital. After the war, they meet each other again going on dates and then, Lon, who is wealthy and handsome, proposes. Meanwhile Noah buys and restores the old house and many people want to buy it. When Allie accidentally sees the photo of Noah and his house in a newspaper, she feels divided between her first love and her commitment with Lon. Meanwhile Duke stops reading to the old lady since his children are visiting him in the nursing home.

In 1957, when second-graders Bryce Loski and Julianna "Juli" Baker first meet, Juli knows it's love, but Bryce isn't so sure and tries to avoid Juli. By the sixth grade, in 1961, Bryce tries to get rid of Juli by dating Sherry Stalls, whom Juli despises. However, Bryce's best friend, Garrett, takes an interest in Sherry and eventually tells her the truth about Bryce asking her out; she doesn't take it well. From Juli's perspective, Bryce returned her feelings, but was shy. After finding out Bryce and Sherry broke up, she thought she could have Bryce back. But then they reconsider their decisions as time goes on. In 1962, Bryce's grandfather Chet Duncan moves in with the family. Chet has different views about Juli. There's a large, old sycamore tree that Juli loves which no one else understands. One day, it's cut down by a group of landscapers so a house can be built there, despite Juli's opposition. She becomes very depressed afterwards, as the tree let her see the world in a more enlightened way. Her father gives her a painting of the tree.

The needy Gigi Haim is a young woman seeking her prince charming somewhere amongst her unsuccessful dates. After dating estate agent Conor Barry, Gigi anxiously expects to receive a phone call from him. However Conor never calls her. Gigi decides to go to the bar where he frequents to see him, but she meets his friend Alex who works there. They become friends and Alex helps Gigi to interpret the subtle signs given out by her dates.

Nursing a secret and hopeless crush on the handsome commuter who passes her booth every day, the charming loner and Chicago "L" ticket seller, Lucy, is about to have a second chance at love. During one seemingly ordinary Christmas shift, Lucy witnesses the object of her desire falling off the platform, and in one of those spur-of-the-moment decisions, she saves him from certain death, only to be mistaken for his fiancée at the hospital. As Lucy enjoys the unexpected stroke of good luck, unable to tell the truth to his welcoming family, unforeseen romantic affairs further complicate matters. Now, the comatose patient's suspicious brother, Jack, thinks he's onto something. Will Lucy face the consequences of what happened while the beautiful stranger was sleeping?

Griffin is divorced, living in a flat in Manhattan while his sons and ex live in the family home in Westchester. He gets bad news from his oncologist: cancerous lesions have spread through his chest, and he has only a year or so to live. He audits a psychology class on death and dying at a nearby college where he chats up a woman who turns out to be an assistant dean. She's Phoenix; she smiles but keeps her distance, warming to him slowly. He tells her nothing of his situation. At his apartment a few days later, she finds a stash of books on death, dying, and terminal illness: will she put two and two together, and what will she do about it?

Leo and Paige are a couple who just got married. After an accident, Paige is left unconscious, and when she awakes she doesn't remember Leo. Her parents, whom she hasn't seen since she and Leo got together, come and visit her. She can't believe that she hasn't seen them for such a long time. Leo wants to bring her home with him but her parents want her to go with them. She goes with Leo but when she doesn't recognize anything, she goes to her parents. And she wonders why did she cut off contact with her family. She also runs into her ex and wonders why they broke up. Leo tries to win her back by courting her again.

Adapted from William Shakespeare's play "The Taming of the Shrew," 10 Things I Hate About You starts off with Cameron, new student at Padua High, sitting in the office of the quirky guidance counselor Ms. Perky. He is then shown around the school by Michael, who will become his best friend. During his tour is when Cameron first sees Bianca Stratford, a beautiful sophomore with one problem: she isn't allowed to date. And neither is her "shrew" sister, Katarina, a senior who loves indie rock and feminist prose and hates conformity. But Kat and Bianca's father alters his house rule: now, Bianca can date... as long as Kat has a date, too. Now, in order for Cameron to date Bianca, he has to find someone to date Kat. So Michael helps him enlist the help of pretty-boy/jerk/model Joey Donner, tricking him into thinking that *he* will get to take Bianca out if he pays someone to take out Kat. His choice: Patrick Verona, a bad-boy with a mysterious reputation--some say he ate a live duck once, others that he lit a state trooper on fire, and even more claim that he had a brief porn career. Will Patrick win Kat's heart? Will Cameron win Bianca's? Or will everything hit the fan...?

For three years, Andrew Paxton has slaved as the assistant to Margaret Tate, hard-driving editor at a New York publisher. When Margaret, a Canadian, faces deportation for an expired visa, she hatches a scheme to marry Andrew - he agrees if she'll promise a promotion. A skeptical INS agent vows to test the couple about each other the next Monday. Andrew had plans to fly home that weekend for his grandma's 90th, so Margaret goes with him - to Sitka, Alaska - where mom, dad, and grams await. Family dynamics take over: tensions between dad and Andrew, an ex-girlfriend, Andrew's dislike of Margaret, and her past color the next few days, with the INS ready to charge Andrew with fraud.