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Late Night with David Letterman is an American late-night talk show hosted by David Letterman on NBC, the first iteration of the Late Night franchise. It premiered on February 1, 1982, and was produced by Letterman's production company, Worldwide Pants Incorporated, and Carson Productions. Letterman had previously hosted his own morning talk show on NBC from June to October 1980. The show's house band, The World's Most Dangerous Band, was led by music director Paul Shaffer. In 1993, Letterman announced that he would leave NBC to host the Late Show with David Letterman on CBS, and the final episode of Late Night aired on June 25, 1993. The series has since been reformatted as Late Night with Conan O'Brien, Late Night with Jimmy Fallon and Late Night with Seth Meyers.

Late Night with Seth Meyers is an American late-night news and political satire talk show hosted by Seth Meyers on NBC. The show premiered on February 24, 2014, and is produced by Broadway Video and Universal Television. Airing weeknights at 12:37 a.m. ET/PT, it is the fourth iteration of NBC's Late Night franchise.

Conan is an American variety and late-night talk show that aired each Monday through Thursday at 11:00 p.m. Eastern time on TBS in the United States. The show premiered on November 8, 2010, and was hosted by writer, comedian, and performer Conan O'Brien, accompanied by his long-time sidekick Andy Richter. Running for eight years and identifying as a traditional late-night talk show, Conan drew its comedy from recent news stories, political figures, and prominent celebrities, as well as aspects of the show itself. The hour-long show was akin to O'Brien's previous NBC late-night shows and was directed by Billy Bollotion.

Starting January 22, 2019, the show was reformatted to a half-hour length. In November 2020, TBS announced that the show would air its final episode in June 2021. The final episode aired on June 24, 2021.

The Tonight Show Starring Jimmy Fallon is an American late-night talk show hosted by actor and comedian Jimmy Fallon that airs on NBC. The show premiered on February 17, 2014, and is produced by Broadway Video and Universal Television. It is the seventh incarnation of NBC's long-running Tonight Show franchise, with Fallon serving as the sixth host. The show also stars sidekick and announcer Steve Higgins and house band The Roots. The Tonight Show is produced by Katie Hockmeyer and executive-produced by Lorne Michaels. The show records from Studio 6B in Rockefeller Center, New York City, which is the same studio in which Tonight Starring Jack Paar and then The Tonight Show Starring Johnny Carson were produced from 1957 until 1972.