Mononoke follows a wandering, nameless character known only as the "Medicine Seller". The series is composed out of 5 story arcs, each featuring the medicine seller as he tries to solve the mystery behind the existence of various Mononoke, evil spirits that still linger in the human world. He combats them using his vast knowledge of the supernatural, but a Mononoke can only be slain after he uncovers its form (Katachi), the truth behind its appearance (Makoto) and the reason for its unusual behavior (Kotowari).

The surreal life of Salad Fingers, an unknown creature living in an apocalyptic wasteland.

Takao worships the class beauty, Nanako, from afar. When he is alone in the classroom one day after school, he notices her bag of gym clothes on the floor. He can't resist picking it up. He plans to return it, but the next day, all the girls are commiserating with Nanako that some pervert has stolen her gym clothes. Worse than that, their classmate Sawa quietly lets him know that she saw him take the clothes and will tell Nanako if he doesn't make a contract with her to do whatever she asks of him and then their strange relationship begins.

Nanako and her childhood friend Tomoko enter a special all-girl high school where students are rich upper class. The series is about events that take place during her schooldays, which she chronicles in letters she sends to her brother.

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