An eccentric scientist changes the world with his teleportation technology: when his experiment seems to be going well, Dr. Seth Brundle tests his machine on himself and he gets fused with the worst kind of pest on Planet Earth; The Fly. What is the price of a man playing God? Only Seth knows.

On the night of her wedding, Justine (Kirsten Dunst) is struggling to be happy even though it should be the happiest day of her life. It was an extravagant wedding paid for by her sister and brother-in-law who are trying to keep the bride and all the guests in line. Meanwhile, Melancholia, a blue planet, is hurtling towards the Earth. Claire (Charlotte Gainsbourg), Justine's sister, is struggling to maintain composure with fear of the impending disaster.

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