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As any detective can tell you, investigating missing property or deaths is comparatively easy compared to elusive missing people. However in New York City, there is a special unit of the FBI that is designed to find them. Using the vast resources of their bureau, the team, lead by Agent Jack Malone, race against time in the tight 72 hour window after a disappearance while hope for a recovery is still typically possible.

A superstar magician Cameron Black whose career is ruined by scandal has only one place to turn to practice his art of deception, illusion, and influence, the FBI where he'll become the world's first consulting illusionist, helping the government solve crimes that defy explanation, and trap criminals and spies by using deception.

Mary Shannon is a U.S. Marshal in the witness protection program who spends her time relocating federal witnesses.. Based in Albuquerque, New Mexico, Mary works with her partner, Marshall Mann, to place criminals and innocent witnesses into new lives. When not putting her life on the line to protect federal witnesses, Mary attempts to manage her dysfunctional family, including overly dependent mother, Jinx, and younger sister, Brandi, both of whom live with her. Between work and family, Mary has little time for boyfriend Raphael Ramirez who plays minor league baseball.

Former CIA operative is lured back to his old life when the NYPD needs his help to stop a serial killer. Dr. Dylan Reinhart (Alan Cumming) is a gifted author and university professor living a quiet life teaching psychopathic behavior to packed classes of adoring students. But when top NYPD detective Lizzie Needham (Bojana Novakovic) appeals to him to help her catch a serial murderer who is using Dylan's first book as a tutorial, Dylan is compelled by the case, comes out of retirement and taps into his old skill set. Though Dylan and Lizzie initially clash, when it comes to catching killers, they realize they will make an ideal team if they both trust their instincts. Based on the James Patterson book.

Lilly Rush is a Philadelphia police detective working for the department's homicide squad and being assigned "cold cases": crimes that were committed many years before and have not been solved. Lilly must try to re-think the crime scenes and interview other people involved with the victims to find a link to solving the cases.

On the streets of San Francisco a team of the Federal Bureau of Investigation's Behavioral Analysis Unit use profiling to catch some of the most horrific serial killers and unidentifiable subjects.

Carrie Wells, a former police detective, has a rare ability to remember virtually everything she experiences including detailed visual recall. She returns to police work and uses her ability to solve crimes.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

Dr. Daniel Pierce is an eccentric neuropsychiatrist who uses his unique outlook to help the federal government solve complex criminal cases.

Deputy Police Chief Brenda Leigh Johnson, formerly Atlanta police officer and CIA-trained interrogator, is given the opportunity to run her own division of elite officers of the Los Angeles Police Department. Her unusual procedure for obtaining confessions, blatant disregard for politics, and southern accent make her a marked woman. However, with all the bluster and bravado, she still maintains her title, The Closer.

A private investigator in Los Angeles reluctantly teams up with a former star of a hit cop show.

Detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles team up to solve crimes in Boston.

A homicide detective, a medical examiner, a newspaper reporter and a young assistant district attorney work together to solve homicide investigations.

Brilliant LAPD detective Charlie Crews has survived the extreme abuse befalling an innocent cop in prison, and was exonerated for the murders and released after 12 years of hell in jail. He could retire on his settlement, but chooses to resume police work. Nevertheless, the grim experience has made him more philosophical and tempted to put justice - especially for the innocent - above chasing the presumably guilty and legally by-the-book, as his new partner Dani Reese must experience and learn to cope with.

Having lost her medical license in the aftermath of a family tragedy, Megan Hunt M.D. joined the medical examiners and proved herself a forensic genius. Yet even diplomatic Medico-legal Investigator Pete Dunlop can't prevent her arrogant attitude and total disregard for any authority or social norm to cause grave aggravation all around. Still, as long as the perpetrators suffer most, the bulldozer approach pays off on the balance.

Dr. Cal Lightman teaches a course in body language and makes an honest fortune exploiting it. He's employed by various public authorities in various investigations, doing more when the police etc. fail to go the extra mile. So he can afford to constitute a team of his own, which like clients and others has to put up with his mind-games.

After the unsolved murder of his wife, Trudy, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

This "Closer" spinoff follows cases handled by the Major Crimes division of the LA Police Department. The 7-member team is headed by Capt. Sharon Raydor, whose intellectual smarts combined with a calm, even temperament help a team of experts solve high-profile murder cases. In addition to running the show, Raydor helps guide and protect her teenage charge, a witness in a horrific crime, who finds a safe refuge among members of the major-case squad.