Danny Rose is a manager of artists, and although he's not very successful, he nevertheless goes out of his way to help his acts. So when Lou Canova, a singer who has a chance of making a come-back, asks Danny to help him with a problem, Danny helps him. This problem is Lou's mistress Tina. Lou wants Tina to be at his concerts, otherwise he can't perform, but he's married, so Danny has to take her along as if she was his girlfriend. Danny however gets more than he has bargained for when two mobsters come looking for the guy who has hurt their brother by stealing the heart of Tina, the girl he loves.

Renowned filmmaker Sandy Bates is in a professional transition, directing largely comedies early in his career now wanting to direct more serious movies so that he can explore the meaning of life, most specifically his own. Most are fighting him all along the way, including the movie going public, who continually tell him that they love his movies especially the earlier funny ones, to studio executives who are trying to insert comic elements wherever possible into his current movie in production. He reluctantly agrees to attend a weekend long film festival of his movies. Despite the throng of requests for his time, he is further able to reflect on his life as he addresses the questions at the post screening Q&A sessions. He also reflects specifically on his love life as his current girlfriend, married Isobel, shows up unexpectedly, and as he starts to fall for festival attendee Daisy - at the festival with her Columbia professor boyfriend, Jack Abel - who reminds him of Dorrie, a neurotic former girlfriend who he probably considers the one that unfortunately got away.

Judah Rosenthal is an ophthalmologist and a pillar of the community who has a big problem: his mistress Dolores Paley has told him that he is to leave his wife and marry her - as he had promised to do - or she will tell everyone of their affair. When he intercepts a letter Dolores has written to his wife Miriam, he is frantic. He confesses all to his shady brother Jack who assures him that he has friends who can take care of her. Meanwhile, filmmaker Cliff Stern is having his own problems. He's been working on a documentary film for some time but has yet to complete it. He and his wife Wendy have long ago stopped loving one another and are clearly on their way to divorce. He falls in love with Halley Reed who works with a producer, Lester. Cliff soon finds himself making a documentary about Lester and hates every minute of it.

Forty-two year old Isaac Davis has a romanticized view of his hometown, New York City, most specifically Manhattan, as channeled through the lead character in the first book he is writing, despite his own Manhattan-based life being more of a tragicomedy. He has just quit his job as a hack writer for a bad television comedy, he, beyond the ten second rush of endorphins during the actual act of quitting, now regretting the decision, especially as he isn't sure he can live off his book writing career. He is paying two alimonies, his second ex-wife, Jill Davis, a lesbian, who is writing her own tell-all book of their acrimonious split. The one somewhat positive aspect of his life is that he is dating a young woman named Tracy, although she is only seventeen and still in high school. Largely because of their differences a big part of which is due to their ages, he does not see a long term future with her. His life has the potential to be even more tragicomical when he meets journalist Mary Wilkie, the mistress of his best friend, college professor Yale Pollack. Although Isaac's first impression of Mary is that she is a pretentious intellectual, he falls for her. They do become friends with the potential of becoming more than just friends as she knows that being the "other woman" in Yale's life is not a long term role that she wants. An Isaac/Mary coupling may complicate matters even more with Yale being mutually in their lives. Regardless, Isaac may be able to rationalize events after they happen, no matter what those events are.

Alvy Singer, a forty year old twice divorced, neurotic, intellectual Jewish New York City stand-up comic, reflects on the demise of his latest relationship, to Annie Hall, an insecure, flighty, Midwestern WASP aspiring nightclub singer. Unlike his previous relationships, Alvy believed he may have worked out all the issues in his life through fifteen years of therapy to make this relationship with Annie last, among those issues being not wanting to date any woman that would want to date him, and thus subconsciously pushing those women away. Alvy not only reviews the many ups and many downs of their relationship, but also reviews the many facets of his makeup that led to him starting to date Annie. Those facets include growing up next to Coney Island in Brooklyn, being attracted to the opposite sex for as long as he can remember, and enduring years of Jewish guilt with his constantly arguing parents.

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