Ron Hall (Greg Kinnear) lost track of what matters most in life. It took an affair, a confession, a dream and an unlikely friendship with a homeless man to help him remember. From the outside, Ron Hall's seemingly charmed life looked pretty perfect: He had a flourishing art business, a beautiful wife, Debbie (Renée Zellweger), two fine teen children, and an amazing fifteen thousand square foot house in Fort Worth, Texas. But appearances can be deceptive.

In Los Angeles, the eleven year old Anna Fitzgerald seeks the successful lawyer Campbell Alexander trying to hire him to earn medical emancipation from her mother Sara that wants Anna to donate her kidney to her sister. She tells the lawyer the story of her family after the discovery that her older sister Kate has had leukemia; how she was conceived by in vitro fertilization to become a donor; and the medical procedures she has been submitted since she was five years old to donate to her sister. Campbell accepts to work pro bono and the obsessed Sara decides to go to court to force Anna to help her sister.

Frank Adler (Chris Evans) is a single man raising a child prodigy - his spirited young niece Mary (Mckenna Grace) in a coastal town in Florida. Frank's plans for a normal school life for Mary are foiled when the seven-year-old's mathematical abilities come to the attention of Frank's formidable mother Evelyn (Lindsay Duncan) whose plans for her granddaughter threaten to separate Frank and Mary. Octavia Spencer plays Roberta, Frank and Mary's landlady and best friend. Jenny Slate is Mary's teacher, Bonnie, a young woman whose concern for her student develops into a connection with her uncle as well.

In Manhattan, 10-year-old Gabe finds his first love when he meets his former kindergarten mate, eleven-year-old Rosemary, in his karate classes. Confused with his new feelings and with the divorce process of his beloved parents, Leslie and Adam, he experiences the delightful unknown sensation of being in love for the first time.

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