Frustrated with his most recent film doing poorly, film director Able Whitman finds himself at a strip club where he meets and takes home one of the strippers, Gigi Stops. They have an accident on the road which kills Gigi leaving Able to figure out what to do with the body. He conveniently decides to "disguise" the body parts as set pieces to his new horror film. When this new design style is met with much praise, Able decides he needs more parts to fulfill his new "project".

Inexplicably, a lively young woman is slowly dying. What started as a rash and a grotesque dark bruise, it keeps spreading, and, even though she still holds on, a terrible scourge is eating her alive from the inside. Now, her job at the hospital, her friends, and her love life have all become fractions of a once-regular life, as, sooner or later, her body will blemish from the blooming flowers of decay, and the stigmata of an unfathomable punishment that demands a transcendental change. Little by little--as the festering wounds claim the remaining flesh--the woman finds herself reduced to a mere fragment of her former self, with a few grim Polaroids being the only remnants of her existence. Inevitably, before Death's omnipotence, any resistance is futile, as the feeble and malleable flesh succumbs to life's ultimate truth: what was once alive, undoubtedly, shall perish.

In this "lost slasher film from 1978," a masked killer wages an unrelenting spree of murder, cannibalism, and necrophilia. But when his tortured past comes back to haunt him, he plunges to even greater depths of madness and depravity, consuming the lives of a young woman and those she holds dear.

In New York, the former NYPD detective Ben Carson is hired to work as night watch of the remains of the Mayflower Department Store that was partially destroyed by fire many years ago. Ben became alcoholic and was retired from the police force after killing a man in a shooting. His marriage was also destroyed and now he is living in the apartment of his younger sister Angie. However he has not been drinking for three months and sees the employment as a chance to rebuild his life. When he goes to the rounds in his first night, he finds that the mirrors are impeccably clean and his colleague explains that the former night watch was obsessed with the mirrors. After a couple of nights, Ben sees weird images in the mirrors, but due to the lack of credibility of his past, his ex-wife Amy believes he has hallucinations as a side effect of his medication. When Angie is found brutally murdered in her bathtub, Ben discovers that there is an evil force in the mirror that is chasing him and jeopardizing his family.

American best friends Josh and Pax, staying at hostels along the way, decide to backpack through Europe following college graduation to indulge in all their hedonistic fantasies in part to help Josh recover from the heartache of a breakup. Josh ends up being more willing in spirit than he is in body. In Paris, they meet Icelandic Oli, who joins them as he is in the same pursuit, he even more open to those indulgences. They believe they can't surpass their experiences in Amsterdam until they are told of a hostel in Slovakia just outside of Bratislava where their sexual experiences can be taken to the next level. There, they initially find that the stories are nothing compared to their actual experiences, far exceeding their expectations. However, those fantasies quickly turn to nightmares as they end up separated by design, their new hell from which they may never be able to escape.

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