Wanting to learn from the best, aspiring boxer Maggie Fitzgerald (Hilary Swank) wants Frankie Dunn (Clint Eastwood) to train her. At the outset, he flatly refuses saying he has no interest in training a girl. Frankie leads a lonely existence, alienated from his only daughter and having few friends. Maggie's rough around the edges, but shows a lot of grit in the ring and he eventually relents. Maggie not only proves to be the boxer he always dreamed of having under his wing, but a friend who fills the great void he's had in his life. Maggie's career skyrockets, but an accident in the ring leads her to ask Frankie for one last favor.

Nurse Caroline Ellis quits her job to take care of elderly Ben Devereux who had a stroke and can't talk. When she gets to his house in Terrebonne Parish, Louisiana, she meets Ben's wife Violet, who acts suspicious and creepy. The family's lawyer, Luke Marshall, convinces Caroline to stay. She goes to the attic and finds a secret room there full of spells, hair, and bones used to practice Hoodoo, but Violet says she has never seen this secret room. Caroline wants to help Ben, thinking that Violet has put a spell on him. She knows Hoodoo can't hurt someone who doesn't believe in it. Can Caroline save Ben, or will she end up being the one who needs to be saved?

Driving cross-country, Ray and his wife and daughter stop at a highway rest area where his daughter falls and breaks her arm. After a frantic rush to the hospital and a clash with the check-in nurse, Ray is finally able to get her to a doctor. While the wife and daughter go downstairs for an MRI, Ray, exhausted, passes out in a chair in the lobby. Upon waking up, they have no record or knowledge of Ray's family ever being checked in.

Trevor Reznik is a machinist in a factory. An extreme case of insomnia has led to him not sleeping in a year, and his body withering away to almost nothing. He has an obsessive compulsion to write himself reminder notes and keep track of his dwindling weight, both scribbled on yellow stickies in his apartment. The only person he lets into his life in an emotional sense is Stevie, a prostitute, although he has an infatuation with Maria, a single mother waitress working in an airport diner. His co-workers don't associate with and mistrust him because of not knowing what is going on in his life that has led to his emaciated physical appearance. A workplace incident further alienates him with his coworkers, and in conjunction with some unfamiliar pieces of paper he finds in his apartment, Trevor believes that someone or some people - probably one or some of his coworkers - are out to get him, using a phantom employee named Ivan as their front. As Trevor goes on a search for evidence as to Ivan's schemes and whereabouts, Trevor may come to a true understanding of what has caused his insomnia.

While moving into a secluded mansion, a young loving couple, Kate and Matt discovers a strange secret room, whose interior holds the power to make everything they want a reality. Millions of dollars, the original of Van Gogh and the most luxurious outfits - whatever they want, instantly materializes. One day, she decides to ask the room to grant them the child they haven't been able to have. But their initial happiness from this blessing will have unforeseen consequences. As they say: careful what you wish for.

Malcolm Rivers has been convicted as the perpetrator of several murders and is sentenced to death. An 11th-hour defense by his lawyers and psychiatrist that Malcolm is insane based on new evidence has resulted in them meeting with the prosecutors and the judge to discuss whether the verdict should be overturned. Meanwhile, on a dark night during a torrential rainstorm in the Nevada desert, a series of chain-reaction events results in several people needing to stay at an out-of-the-way motel managed by Larry. They are: ex-cop, now limo driver Ed and his client Caroline, a diva of a once-famous actress; quiet adolescent Timmy, his stepfather George, and his mother Alice, who was seriously injured when Ed accidentally ran over her as she watched George change their flat tire; prostitute Paris, who was the unwitting cause of George's flat tire; newlyweds Lou and Ginny, whose marriage is based on a lie; and Police Officer Rhodes, who was en route escorting prisoner Robert to his new institution. None can leave because of washed-out roads, all the other businesses around the motel are closed because of the storm, and all communication in and out is not functioning also because of the storm. One by one, they are murdered, the murderer leaving a calling card of a motel room key, starting with the room 10 key and working his way presumably to the room 1 key when the last person will be dead. Those still alive band somewhat together under Officer Rhodes and Ed's direction to find out which of the 11 is the murderer, and if, based on one of their theories, that they were brought to the motel by some force by the murderer as his intended targets. Whether those still alive can discover who the murderer is, discover why he has chosen to kill them, and be able to subdue him may well determine Malcolm's fate.

In 1954, up-and-coming U.S. marshal Teddy Daniels is assigned to investigate the disappearance of a patient from Boston's Shutter Island Ashecliffe Hospital. He's been pushing for an assignment on the island for personal reasons, but before long he thinks he's been brought there as part of a twisted plot by hospital doctors whose radical treatments range from unethical to illegal to downright sinister. Teddy's shrewd investigating skills soon provide a promising lead, but the hospital refuses him access to records he suspects would break the case wide open. As a hurricane cuts off communication with the mainland, more dangerous criminals "escape" in the confusion, and the puzzling, improbable clues multiply, Teddy begins to doubt everything - his memory, his partner, even his own sanity.

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